Plasma membrane calcium pumps and their emerging roles in cancer

Roberts-Thomson, Sarah J., Curry, Merril C. and Monteith, Gregory R. (2010) Plasma membrane calcium pumps and their emerging roles in cancer. World Journal of Biological Chemistry, 1 8: 248-253. doi:10.4331/wjbc.v1.i8.248

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Author Roberts-Thomson, Sarah J.
Curry, Merril C.
Monteith, Gregory R.
Title Plasma membrane calcium pumps and their emerging roles in cancer
Journal name World Journal of Biological Chemistry   Check publisher's open access policy
ISSN 1949-8454
Publication date 2010-08-26
Sub-type Article (original research)
DOI 10.4331/wjbc.v1.i8.248
Open Access Status DOI
Volume 1
Issue 8
Start page 248
End page 253
Total pages 6
Place of publication Beijing, China
Publisher Beijing Baishideng BioMed Scientific Co
Collection year 2011
Language eng
Subject C1
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
920102 Cancer and Related Disorders
Abstract Alterations in calcium signaling and/or the expression of calcium pumps and channels are an increasingly recognized property of some cancer cells. Alterations in the expression of plasma membrane calcium ATPase (PMCA) isoforms have been reported in a variety of cancer types, including those of breast and colon, with some studies of cancer cell line differentiation identifying specific PMCA isoforms, which may be altered in some cancers. Some studies have also begun to assess levels of PMCA isoforms in clinical tumor samples and to address mechanisms of altered PMCA expression in cancers. Both increases and decreases in PMCA expression have been reported in different cancer types and in many cases these alterations are isoform specific. In this review, we provide an overview of studies investigating the expression of PMCA in cancer and discuss how both the overexpression and reduced expression of a PMCA isoform in a cancer cell could bestow a growth advantage, through augmenting responses to proliferative stimuli or reducing sensitivity to apoptosis.
Keyword Plasma membrane calcium ATPase
Calcium pump
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Pharmacy Publications
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Created: Tue, 19 Oct 2010, 12:11:02 EST by Charna Kovacevic on behalf of School of Pharmacy