Ductus venosus velocimetry in monitoring pregnancy in women with pregestational diabetes mellitus

Wong, S. F., Petersen, S. G., Idris, N., Thomae, M. and McIntyre, H. D. (2010) Ductus venosus velocimetry in monitoring pregnancy in women with pregestational diabetes mellitus. Ultrasound in Obstetrics and Gynecology, 36 3: 350-354. doi:10.1002/uog.7744

Author Wong, S. F.
Petersen, S. G.
Idris, N.
Thomae, M.
McIntyre, H. D.
Title Ductus venosus velocimetry in monitoring pregnancy in women with pregestational diabetes mellitus
Journal name Ultrasound in Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0960-7692
Publication date 2010-09-01
Sub-type Article (original research)
DOI 10.1002/uog.7744
Volume 36
Issue 3
Start page 350
End page 354
Total pages 5
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Formatted abstract
Objective The purpose of this research was to assess
the ability of ductus venosus (DV) Doppler velocimetry
to predict adverse perinatal outcome in pregnancies
complicated by pre-existing diabetes mellitus.

Methods This was a prospective study conducted at a
tertiary referral obstetric facility in Brisbane, Australia.
The study group included women with pregestational
diabetes mellitus who delivered in the hospital between
1 January 1995 and 31 December 2006. The DV
Doppler index was defined as abnormal if the DV peak
velocity index for veins (PVIV) was equal to or greater
than the 95th percentile for gestation. Adverse perinatal
outcome included one or more of the following criteria:
small-for-gestational-age infant; Cesarean section for nonreassuring
fetal status; fetal acidemia at delivery; a 1-min
Apgar score of ≤3; a 5-min Apgar score of <7; hypoxic
ischemic encephalopathy; and stillbirth or neonatal death.
The maternal characteristics and perinatal outcomes of
pregnancieswith normal or abnormalDVDoppler indices
were compared.

Results Eighty-two pregestational diabetic pregnancies
were studied and an abnormal DV-PVIV was identified
in 25 (30.5%). Adverse perinatal outcome was identified
in eight of 25 (32.0%) pregnancies with an abnormal
DV-PVIV compared to seven of 57 (12.3%) pregnancies
with a normal DV-PVIV (P < 0.05). The sensitivity of
the DV-PVIV in predicting adverse perinatal outcomes
in pregestational diabetic pregnancies was 53.3%, the
specificity was 74.6%, the positive predictive value was
32.0% and the negative predictive value was 87.7%.

Conclusion It may be useful to include DV-PVIV in
the antenatal screening of pregnancies complicated by pregestational diabetes. Copyright © 2010 ISUOG.
Published by John Wiley & Sons, Ltd.
Keyword Diabetes mellitus
Ductus venosus
Perinatal outcome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Created: Sun, 17 Oct 2010, 10:00:23 EST