Kidney development: Two tales of tubulogenesis

Little, Melissa, Georgas, Kylie, Pennisi, David and Wilkinson, Lorine (2010) Kidney development: Two tales of tubulogenesis. Current Topics in Developmental Biology, 90 C: 193-229. doi:10.1016/S0070-2153(10)90005-7

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Author Little, Melissa
Georgas, Kylie
Pennisi, David
Wilkinson, Lorine
Title Kidney development: Two tales of tubulogenesis
Journal name Current Topics in Developmental Biology   Check publisher's open access policy
ISSN 0070-2153
ISBN 9780123809124
Publication date 2010-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0070-2153(10)90005-7
Volume 90
Issue C
Start page 193
End page 229
Total pages 37
Place of publication San Diego, CA, U.S.A
Publisher Academic Press
Language eng
Abstract The mammalian kidney may well be one of the most complex organs of postnatal life. Each adult human kidney contains on average more than one million functional filtration units, the nephrons, residing within a specialized cellular interstitium. Each kidney also contains over 25 distinct cell types, each of which must be specifically aligned with respect to each other to ensure both normal development and ultimately, normal renal function. Despite this complexity, the development of the kidney can be simplistically described as the coordinate formation of two distinct sets of tubules. These tubules develop cooperatively with each other in time and space, yet represent two distinct but classical types of tubulogenesis. The first of these tubules, the ureteric bud, forms as an outgrowth of another epithelial tube, the nephric duct, and undergoes extensive branching morphogenesis to create the collecting system of the kidney. The second tubules are the nephrons themselves which arise via a mesenchyme-to-epithelial transition induced by the first set of tubules. These tubules never branch, but must elongate to become intricately patterned and functionally segmented tubules. The molecular drivers for these two tales of tubulogenesis include many gene families regulating tubulogenesis and branching morphogenesis in other organs; however, the individual players and codependent interrelationships between a branched and non-branched tubular network make organogenesis in the kidney unique. Here we review both what is known and remains to be understood in kidney tubulogenesis. © 2010 Elsevier Inc.
Keyword Kidney development
Metanephric mesenchyme
Ureteric bud
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 45 times in Scopus Article | Citations
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Created: Sun, 03 Oct 2010, 10:02:08 EST