Hyperinsulinemic laminitis

de Laat, Melody A., McGowan, Catherine M., Sillence, Martin N. and Pollitt, Christopher C. (2010) Hyperinsulinemic laminitis. Veterinary Clinics of North America: Equine Practice, 26 2: 257-264. doi:10.1016/j.cveq.2010.04.003

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Author de Laat, Melody A.
McGowan, Catherine M.
Sillence, Martin N.
Pollitt, Christopher C.
Title Hyperinsulinemic laminitis
Journal name Veterinary Clinics of North America: Equine Practice   Check publisher's open access policy
ISSN 0749-0739
Publication date 2010-08-01
Sub-type Article (original research)
DOI 10.1016/j.cveq.2010.04.003
Open Access Status Not yet assessed
Volume 26
Issue 2
Start page 257
End page 264
Total pages 8
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Language eng
Abstract Laminitis occurring in association with hyperinsulinemia is frequently encountered in today's equine population. New evidence suggests that hyperinsulinemia is the direct cause of this form of laminitis, rather than insulin resistance per se. The mechanism by which elevated serum insulin concentrations result in lamellar dysfunction is currently under investigation by many researchers and the use of a new insulin infusion model for investigating the pathogenesis of insulin-associated laminitis will doubtless enhance progress in this field of research. By focusing on the metabolic and vascular actions of insulin in the lamellar microenvironment, our research group is trying to gain an insight into the pathophysiological processes involved in this complex problem, in order to better understand the disease. Copyright © 2010 Saunders, An Imprint of Elsevier
Keyword Hyperinsulinemia
Insulin resistance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Sun, 26 Sep 2010, 10:00:39 EST