Human fatality associated with Pacific ciguatoxin contaminated fish

Hamilton, Brett, Whittle, Nigel, Shaw, Glen, Eaglesham, Geoff, Moore, Michael R. and Lewis, Richard J. (2010) Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon, 56 5: 668-673. doi:10.1016/j.toxicon.2009.06.007

Author Hamilton, Brett
Whittle, Nigel
Shaw, Glen
Eaglesham, Geoff
Moore, Michael R.
Lewis, Richard J.
Title Human fatality associated with Pacific ciguatoxin contaminated fish
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 2010-10-01
Sub-type Article (original research)
DOI 10.1016/j.toxicon.2009.06.007
Open Access Status Not Open Access
Volume 56
Issue 5
Start page 668
End page 673
Total pages 6
Place of publication United Kingdom
Publisher Elsevier Science
Language eng
Formatted abstract
Ciguatera is a food poisoning identified as the principal risk factor in the consumption of tropical fish in Oceania. The syndrome, which follows ingestion of ciguatoxin-contaminated ciguateric fishes, is characterised by an array of gastrointestinal and neurological features. In this report we examine forensic samples associated with a human fatality using a 3H-brevetoxin binding assay and reversed-phase HPLC/MS and HPLC/MS/MS. Three Pacific ciguatoxins (P-CTX) were detected in the implicated fish flesh sample by LC-MS/MS, implicating multiple P-CTXs in the fatal case. Additionally, ciguatoxin was identified in a liver sample obtained at post-mortem. The level of ciguatoxin detected (0.14 ppb P-CTX-1 equivalents by binding assay) indicated that at least 10% of the ingested P-CTX-1 remained in the human liver 6 days after the toxic fish was consumed. This study confirms the potential of tropical reef fish to accumulate sufficient P-CTX to be lethal to humans, especially if the liver and viscera are consumed as part of the meal. © 2009.
Keyword Ciguatera
Mass spectrometry
Fatal marine poisoning
Pacific ciguatoxin
Oyster Crassostrea-virginica
Jack Caranx-latus
Caribbean Ciguatoxins
Brevetoxin Metabolism
Gambierdiscus toxicus
Controlled Exposures
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received 6 April 2009; revised 29 May 2009; accepted 4 June 2009. Available online 16 June 2009.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 19 Sep 2010, 10:00:20 EST