Extended-spectrum beta-lactamases: the European experience

Paterson, D.L. (2001) Extended-spectrum beta-lactamases: the European experience. Current Opinion in Infectious Diseases, 14 6: 697-701. doi:10.1097/00001432-200112000-00006


Author Paterson, D.L.
Title Extended-spectrum beta-lactamases: the European experience
Journal name Current Opinion in Infectious Diseases   Check publisher's open access policy
ISSN 0951-7375
Publication date 2001-12-01
Year available 2001
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/00001432-200112000-00006
Open Access Status Not yet assessed
Volume 14
Issue 6
Start page 697
End page 701
Total pages 5
Place of publication London, England
Publisher Gower Academic Journals
Language eng
Subject 1103 Clinical Sciences
Abstract Extended-spectrum beta-lactamases mediate resistance to cephalosporin antibiotics and were first discovered in Europe in the early 1980s. They have become a widespread problem, particularly in Klebsiella pneumoniae, but increasingly in non-typhoid Salmonella species. Traditionally, extended-spectrum beta-lactamases have been derivatives of TEM and SHV parent enzymes. The last year, however, has seen an explosion of developments in extended-spectrum beta-lactamases of non-TEM, non-SHV lineage in Europe. The CTX-M type extended-spectrum beta-lactamases have become particularly widespread. At the same time, European clinical microbiology laboratories have become more aware of the pressing need for detection methods given increasing awareness of the lack of reliability of cephalosporins in the treatment of extended-spectrum beta-lactamase producers. © 2001 Lippincott Williams & Wilkins.
Keyword Intensive-care units
Klebsiella-pneumoniae
Enterobacter-cloacae
3RD-Generation Cephalosporins
Antimicrobial Resistance
Transferable Resistance
Salmonella-typhimurium
Crystal-structure
Escherichia-coli
Cefotaxime
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Centre for Clinical Research Publications
 
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Created: Wed, 08 Sep 2010, 03:05:39 EST