Paediatric HIV infection in a rural South African district hospital

Yeung, S., Wilkinson, D., Escott, S. and Gilks, C.F. (2000) Paediatric HIV infection in a rural South African district hospital. Journal of Tropical Pediatrics, 46 2: 107-110. doi:10.1093/tropej/46.2.107

Author Yeung, S.
Wilkinson, D.
Escott, S.
Gilks, C.F.
Title Paediatric HIV infection in a rural South African district hospital
Journal name Journal of Tropical Pediatrics   Check publisher's open access policy
ISSN 0142-6338
Publication date 2000-04-01
Sub-type Article (original research)
DOI 10.1093/tropej/46.2.107
Open Access Status Not Open Access
Volume 46
Issue 2
Start page 107
End page 110
Total pages 4
Place of publication London, England
Publisher Oxford Journals
Language eng
Subject 1103 Clinical Sciences
1108 Medical Microbiology
1117 Public Health and Health Services
Abstract The objective of this study was to determine the prevalence, clinical spectrum, and outcome of paediatric HIV infection in 281 consecutive children admitted to hospital in rural South Africa between October 1996 and January 1997. HIV infection was defined as two positive ELISAs in those aged > 12 months; a positive ELISA plus a positive IgG3 in those aged 6-12 months; and a positive ELISA plus positive p24 antigen or PCR in those aged 0-5 months. In all, 72 (26 per cent) children were HIV infected. Age-specific HIV prevalence was at least 25 per cent in all 1-5 year age groups. HIV-infected children were more likely to have been previously admitted (46 per cent vs. 23 per cent; p = 0.0002), and were more likely to have severe malnutrition (52 per cent vs. 17 per cent; p < 0.0001). Both HIV-infected and HIV-uninfected most frequently presented with diarrhoeal disease (51 per cent vs. 32 per cent), acute respiratory infection (13 per cent vs. 23 per cent), and malnutrition (18 per cent vs. 11 per cent). Satisfactory response to antibiotic therapy was less likely among the HIV-infected (56 per cent vs. 73 per cent; p = 0.02), and mortality was higher among the HIV-infected (21 per cent vs. 7 per cent; p = 0.005). It is concluded that HIV-infected children present with disease syndromes common to this setting, but do so more frequently and with worse outcome than their uninfected counterparts. The high burden of paediatric HIV disease in this setting poses a substantial challenge for health resources.
Keyword Malnourished Children
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
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Created: Tue, 07 Sep 2010, 23:09:02 EST