Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis

Howes, Mark T., Mayor, Satyajit and Parton, Robert G. (2010) Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis. Current Opinion In Cell Biology, 22 4: 519-527. doi:10.1016/j.ceb.2010.04.001


Author Howes, Mark T.
Mayor, Satyajit
Parton, Robert G.
Title Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis
Journal name Current Opinion In Cell Biology   Check publisher's open access policy
ISSN 0955-0674
1879-0410
Publication date 2010-08-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ceb.2010.04.001
Volume 22
Issue 4
Start page 519
End page 527
Total pages 9
Place of publication Philadelphia PA, USA
Publisher Elseiver
Collection year 2011
Language eng
Subject 0601 Biochemistry and Cell Biology
Abstract Eukaryotic cells deftly coordinate an array of endocytic pathways beyond the classical clathrin-mediated endocytic route. Although the existence of clathrin-independent endocytic pathways has been accepted for some time, only recently have tools been developed that specifically delineate their fine details, including molecular composition and ultrastructural morphology. Identification of the salient features of distinct pathways has concomitantly attributed them with specific roles during important cellular processes. Insight from model organisms confirms these roles and suggests maintenance of crucially adapted functions across species. Among other roles, clathrin-independent endocytosis has now been linked to plasma membrane repair, cellular spreading, cellular polarization, and modulation of intercellular signaling. The field is now primed to identify how these pathways function within physiologically relevant environments. © 2010 Elsevier Ltd.
Keyword Gpi-anchored Proteins
Deficient Muscular-dystrophy
Genome-wide Analysis
Plasma-membrane
Mediated Endocytosis
Directional migration
Integrin Endocytosis
Actin Cytoskeleton
Pinocytic Pathway
Cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 1 May 2010.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
Centre for Microscopy and Microanalysis Publications
 
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Created: Sun, 05 Sep 2010, 10:07:27 EST