Temporal relationships between peripheral plasma concentrations of oxytocin, progesterone and 13,14-dihydro-15-keto-prostaglandin F2α during the oestrous cycle and early pregnancy in the ewe

Webb, R., Mitchell, M.D., Falconer, J. and Robinson, J.S. (1981) Temporal relationships between peripheral plasma concentrations of oxytocin, progesterone and 13,14-dihydro-15-keto-prostaglandin F2α during the oestrous cycle and early pregnancy in the ewe. Prostaglandins, 22 3: 443-453. doi:10.1016/0090-6980(81)90105-2


Author Webb, R.
Mitchell, M.D.
Falconer, J.
Robinson, J.S.
Title Temporal relationships between peripheral plasma concentrations of oxytocin, progesterone and 13,14-dihydro-15-keto-prostaglandin F2α during the oestrous cycle and early pregnancy in the ewe
Journal name Prostaglandins   Check publisher's open access policy
ISSN 0090-6980
Publication date 1981-09-01
Year available 1981
Sub-type Article (original research)
DOI 10.1016/0090-6980(81)90105-2
Open Access Status DOI
Volume 22
Issue 3
Start page 443
End page 453
Total pages 11
Place of publication Stoneham, Ma., U.S.A.
Publisher Butterworths
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Peripheral plasma concentrations of oxytocin, 13,14-dihydro-15-keto-prostaglandin F(PGFM), progesterone and LH were determined at 3 hourly intervals during the oesterous cycle (n = 3) and in early pregnancy (n = 4) in sheep. The progesterone and LH concentrations showed that the cycling ewes were samples during the periods of luteal regression (decreasing progesterone concentrations), the preovulatory gonadotrophin surge and the beginning of the next luteal phase (increasing progesterone concentrations). The pregnant ewes had basal LH concentrations and luteal phase concentrations of progesterone (>lng/ml afte day 5 following mating) throughout the whole of the sampling period. Oxytocin concentrations in the non-pregnant ewes decreased around the time of luteal regression to reach low concentrations (mean concentrations of approximately 18pg/ml) during the preovulatory period and then increased after the preovulatory surge. PGFM concentrations exhibited a pulsatile pattern with increasing concentrations as progesterone levels fell. In the pregnant ewes oxytocin concentrations gradually fell until approximately 16 days post-mating (approximately 7–8pg/ml). The magnitude of the pulses in PGFM concentrations were also lower than in the cycling ewes. These results demonstrate that the increased concentrations of PGFM which are found during the period of luteal regression are not caused by increased peripheral concentrations of oxytocin.
Keyword Biochemistry & Molecular Biology
Cell Biology
Biochemistry & Molecular Biology
Cell Biology
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 23:19:55 EST