Inhibition of prostaglandin synthesis by amniotic fluid of the baboon

Strickland, D.M., Kuehl, T.J., Saeed, S.A. and Mitchell, M.D. (1983) Inhibition of prostaglandin synthesis by amniotic fluid of the baboon. IRCS Medical Science-Biochemistry, 11 2: 138-138.

Author Strickland, D.M.
Kuehl, T.J.
Saeed, S.A.
Mitchell, M.D.
Title Inhibition of prostaglandin synthesis by amniotic fluid of the baboon
Journal name IRCS Medical Science-Biochemistry   Check publisher's open access policy
ISSN 0269-8951
Publication date 1983-01-01
Sub-type Article (original research)
Volume 11
Issue 2
Start page 138
End page 138
Total pages 1
Place of publication Barking, England
Publisher Elsevier Applied Science
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Amniotic fluid was obtained by transabdominal amniocentesis from Savanna baboons between 67 and 173 days gestation (term = 180 ± 7 days, mean ± SEM). To assess the inhibitory activity of the fluids toward the synthesis of prostaglandins we incubated amniotic fluid in various dilutions with bovine seminal vesicle microsomal prostaglandin synthase and then monitored the biosynthesis of prostaglandin E2. The potency of inhibitory activity in amniotic fluid increased as gestation progressed. In late gestation, baboon amniotic fluid, at a concentration of 60% (v/v) caused a 66.2% ± 4.9% (mean ± SEM) inhibition of prostaglandin E2 production. This degree of inhibition of prostaglandin synthesis is comparable to the inhibitory activity of fluid obtained from women at term.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 23:18:24 EST