Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term

Romero, R., Wu, Y.K., Mazor, M., Hobbins, J.C. and Mitchell, M.D. (1989) Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term. Prostaglandins Leukotrienes and Essential Fatty Acids, 35 2: 81-83. doi:10.1016/0952-3278(89)90169-5


Author Romero, R.
Wu, Y.K.
Mazor, M.
Hobbins, J.C.
Mitchell, M.D.
Title Amniotic fluid concentration of 5-hydroxyeicosatetraenoic acid is increased in human parturition at term
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
1532-2823
Publication date 1989-02-01
Sub-type Article (original research)
DOI 10.1016/0952-3278(89)90169-5
Volume 35
Issue 2
Start page 81
End page 83
Total pages 3
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Abstract 5-Hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if spontaneous human labor at term is associated with changes in the concentration of this metabolite in amniotic fluid. Fluid was retrieved from 36 women not in labor and from 30 women in active labor at term. 5-HETE was determined by radioimmunoassay. The median amniotic fluid concentration of 5-HETE of women in labor was significantly greater than that of women not in labor (3538 pg/ml vs. 1977 pg/ml, respectively; p = 0.05). This observation is consistent with activation of the lipoxygenase pathway of arachidonic acid metabolism during spontaneous human parturition at term.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 23:12:30 EST