Amniotic fluid interleukin-1 in spontaneous labor at term

Romero, R., Parvizi, S.T., Oyarzun, E., Mazor, M., Wu, Y.K., Avila, C., Athanassiadis, A.P. and Mitchell, M.D. (1990) Amniotic fluid interleukin-1 in spontaneous labor at term. Journal of Reproductive Medicine, 35 3: 235-238.

Author Romero, R.
Parvizi, S.T.
Oyarzun, E.
Mazor, M.
Wu, Y.K.
Avila, C.
Athanassiadis, A.P.
Mitchell, M.D.
Title Amniotic fluid interleukin-1 in spontaneous labor at term
Journal name Journal of Reproductive Medicine   Check publisher's open access policy
ISSN 0024-7758
Publication date 1990-03-01
Sub-type Article (original research)
Volume 35
Issue 3
Start page 235
End page 238
Total pages 4
Place of publication St.Louis Mo, U.S.A.
Publisher Science Printers and Publishers
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract The regulatory signals responsible for the increased biosynthesis of prostaglandins during parturition have not been established. Interleukin-1 (IL-1) is capable of stimulating prostaglandin production by intrauterine tissues and is an inflammation mediator. It has been postulated as a signal for the onset of labor in the setting of intrauterine infection. A study was designed to determine if spontaneous labor at term was associated with changes in IL-1 activity in amniotic fluid. Such fluid was retrieved from 41 women in labor and from 39 women who were not in labor at term. Immunodetectable IL-1β was present in 22 of the 41 women in labor but in only 8 of the 39 women without labor. IL-1-like bioactivity was not different between the two groups at a dilution of 1:4, but at dilutions of 1:12, 1:36 and 1:108, amniotic fluid from women in labor had significantly higher bioactivity than that from women not in labor. A significant correlation was found between the bioassay and immunoassay results. Our data show that inhibitors of IL-1 bioactivity are present in amniotic fluid and suggest that in a subset of laboring women at term, an inflammatory reaction may play a role in triggering the onset of parturition.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 23:12:03 EST