Placental expression of myostatin and follistatin-like-3 protein in a model of developmental programming

Peiris, HN, Ponnampalam, AP, Osepchook, CC, Mitchell, MD and Green, MP (2010) Placental expression of myostatin and follistatin-like-3 protein in a model of developmental programming. American Journal of Physiology - Endocrinology and Metabolism, 298 4: E854-E861. doi:10.1152/ajpendo.00673.2009

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Author Peiris, HN
Ponnampalam, AP
Osepchook, CC
Mitchell, MD
Green, MP
Title Placental expression of myostatin and follistatin-like-3 protein in a model of developmental programming
Journal name American Journal of Physiology - Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0193-1849
Publication date 2010-04-01
Sub-type Article (original research)
DOI 10.1152/ajpendo.00673.2009
Volume 298
Issue 4
Start page E854
End page E861
Total pages 8
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Maternal undernutrition during gestation is known to be detrimental to fetal development, leading to a propensity for metabolic disorders later in the adult lives of the offspring. Identifying possible mediators and physiological processes involved in modulating nutrient transport within the placenta is essential to prevent and/or develop treatments for the effects of aberrant nutrition, nutrient transfer, and detrimental changes to fetal development. A potential role for myostatin as a mediator of nutrient uptake and transport from the mother to the fetus was shown through the recent finding that myostatin acts within the human placenta to modulate glucose uptake and therefore homeostasis. The mRNA and protein expression of myostatin and its inhibitor, follistatin-like-3 (FSTL3), was studied in the placenta and skeletal muscle of a transgenerational Wistar rat model of gestational maternal undernutrition in which the F2 offspring postweaning consumed a high-fat (HF) diet. Alterations in placental characteristics and offspring phenotype, specifically glucose homeostasis, were evident in the transgenerationally undernourished (UNAD) group. Myostatin and FSTL3 protein expression were also higher (P < 0.05) in the placentae of the UNAD compared with the control group. At maturity, UNAD HF-fed animals had higher (P < 0.05) skeletal muscle expression of FSTL3 than control animals. In summary, maternal undernutrition during gestation results in the aberrant regulation of myostatin and FSTL3 in the placenta and skeletal muscle of subsequent generations. Myostatin, through the disruption of maternal nutrient supply to the fetus, may thus be a potential mediator of offspring phenotype.
Copyright © 2010 the American Physiological Society.
Keyword Undernutrition
Growth differentiating factor-8
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
UQ Centre for Clinical Research Publications
Official 2011 Collection
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 26 Aug 2010, 23:09:28 EST