Paradoxical proinflammatory actions of interleukin-10 in human amnion: potential roles in term and preterm labour

Mitchell, M.D., Simpson, K.L. and Keelan, J.A. (2004) Paradoxical proinflammatory actions of interleukin-10 in human amnion: potential roles in term and preterm labour. Journal of Clinical Endocrinology & Metabolism, 89 8: 4149-4152. doi:10.1210/jc.2004-0373


Author Mitchell, M.D.
Simpson, K.L.
Keelan, J.A.
Title Paradoxical proinflammatory actions of interleukin-10 in human amnion: potential roles in term and preterm labour
Journal name Journal of Clinical Endocrinology & Metabolism   Check publisher's open access policy
ISSN 0021-972X
Publication date 2004-08-01
Sub-type Article (original research)
DOI 10.1210/jc.2004-0373
Volume 89
Issue 8
Start page 4149
End page 4152
Total pages 4
Place of publication Bethesda, MD, U.S. A.
Publisher Endocrine Society
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
IL-10 is regarded predominantly as an inhibitor of cell-mediated inflammatory reactions. As such, it has been suggested that IL-10 could have therapeutic potential, including the treatment of preterm labor. Using explant cultures of gestational membranes we have found that IL-10 does indeed exert anti-inflammatory properties in choriodecidua, but that in the adjacent amnion it has remarkable pro-inflammatory actions. Amnion prostaglandin (PG) E 2 production was significantly increased following 24-h treatment with IL-10 (5-100 ng/mL). Production of IL-8 also showed a significant stimulation at 100 ng/mL IL-10. In contrast, choriodecidual production of IL-8 and tumor necrosis factor (TNF)-α was dramatically inhibited by IL-10, confirming the ability of this tissue to exhibit a classical IL-10 response. IL-10 retained its stimulatory actions on amnion in the presence of IL-1β and TNF-α stimulation. These findings suggest that the fetal membranes can exhibit opposing responses to IL-10, depending on whether the inflammatory insult occurs at the maternal or fetal face. While inflammatory reactions are negatively regulated by IL-10 in choriodecidua, if the pathogen reaches the amnion and threatens the fetus, pro-inflammatory reactions may predominate to ensure successful labor to spare and protect the fetus.
Keyword Necrosis-factor-alpha
Prostaglandin-E2 Production
Human Gestational Tissues
Therapeutic Implications
Differential Regulation
Premature Rupture
Fetal Membranes
H Synthase-2
IL-10
Cytokine
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 23:07:06 EST