Myostatin is a human placental product that regulates glucose uptake

Mitchell, Murray D., Osepchook, Claire C., Leung, Kai-Cheung, McMahon, Christopher D. and Bass, John J. (2006) Myostatin is a human placental product that regulates glucose uptake. Journal of Clinical Endocrinology & Metabolism, 91 4: 1434-1437. doi:10.1210/jc.2005-2361

Author Mitchell, Murray D.
Osepchook, Claire C.
Leung, Kai-Cheung
McMahon, Christopher D.
Bass, John J.
Title Myostatin is a human placental product that regulates glucose uptake
Journal name Journal of Clinical Endocrinology & Metabolism   Check publisher's open access policy
ISSN 0021-972X
Publication date 2006-04-01
Sub-type Article (original research)
DOI 10.1210/jc.2005-2361
Volume 91
Issue 4
Start page 1434
End page 1437
Total pages 4
Place of publication Bethesda, MD U.S.A.
Publisher Endocrine Society
Language eng
Subject 0604 Genetics
1103 Clinical Sciences
Formatted abstract
Myostatin is a member of the TGF-β superfamily and is primarily known for its ability to inhibit muscle growth. It also has actions on glucose metabolism. We hypothesized that it may act as a paracrine regulator of glucose uptake in the placenta, potentially contributing to fetal and placental growth.

The objective of this study was to determine whether myostatin is present in and formed by the human placenta and to evaluate its effects on glucose uptake.

Materials and Methods:
Myostatin protein and mRNA were measured using Western immunoblotting and real-time PCR, respectively. Glucose uptake was assessed by uptake of radiolabeled deoxyglucose in vitro. Placental tissues were obtained at term (n = 8), preterm (n = 8; 24-34 wk), and early in pregnancy (n = 6; 9-13 wk).


Human placentas were shown to express myostatin protein, with a significantly lower expression in term samples compared with samples collected in preterm samples. Human placentas express myostatin mRNA throughout gestation, which does not change. Myostatin treatment of human term placental explants resulted in an increase in deoxyglucose uptake compared with controls.

Myostatin is synthesized, released, and acts within the human placenta. It contributes to placental glucose homeostasis and may be a therapeutic target in diseases ranging from placental insufficiency to diabetes in pregnancy. Copyright © 2006 by The Endocrine Society.
Keyword Skeletal-muscle Mass
Deficient Mice
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 23:06:05 EST