Potential agonist action of the interleukin-1 receptor antagonist protein: Implications for treatment of women

Mitchell, M.D., Edwin, S.S., Silver, R.M. and Romero, R.J. (1993) Potential agonist action of the interleukin-1 receptor antagonist protein: Implications for treatment of women. Journal of Clinical Endocrinology & Metabolism, 76 5: 1386-1388. doi:10.1210/jc.76.5.1386


Author Mitchell, M.D.
Edwin, S.S.
Silver, R.M.
Romero, R.J.
Title Potential agonist action of the interleukin-1 receptor antagonist protein: Implications for treatment of women
Journal name Journal of Clinical Endocrinology & Metabolism   Check publisher's open access policy
ISSN 0021-972X
Publication date 1993-05-01
Year available 1993
Sub-type Other
DOI 10.1210/jc.76.5.1386
Volume 76
Issue 5
Start page 1386
End page 1388
Total pages 3
Place of publication Bethesda, MD, U.S.A.
Publisher Endocrine Society
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract The interleukin-1 receptor antagonist protein (IRAP) caused a concentration-related increase in prostaglandin production by human decidual cells. The degree and time course of this stimulatory action were identical to those induced by interleukin 1β (IL-1β). IRAP had no inhibitory action on IL-1β stimulation of decidual prostaglandin production and at high concentrations had an additive effect. We believe that this represents the first description of a potential agonist action of IRAP and suggests caution in treatment of women with this substance.
Keyword Prostaglandin Biosynthesis
Preterm Labor
Expression
Cells
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Other
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 23:03:16 EST