Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells

Mitchell, Murray D., Dudley, Donald J., Edwin, Samuel S. and Schiller, Sarah Lundin (1991) Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells. European Journal of Pharmacology, 192 1: 189-191. doi:10.1016/0014-2999(91)90090-D


Author Mitchell, Murray D.
Dudley, Donald J.
Edwin, Samuel S.
Schiller, Sarah Lundin
Title Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
1879-0712
Publication date 1991-01-03
Sub-type Other
DOI 10.1016/0014-2999(91)90090-D
Volume 192
Issue 1
Start page 189
End page 191
Total pages 3
Place of publication The Netherlands
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract The effects of interleukin-6 on prostaglandin production by cells from two key sources on intrauterine prostaglandin, i.e. amnion and decidua, have been evaluated. Interleukin-6 induced a concentration-related increase in prostaglandin production by amnion and decidual cells. The concentrations of interleukin-6 required for this stimulatory action are within the range measured in amniotic fluid of women with intrauterine infections and preterm labor. Hence, interleukin-6 may contribute to the mechanism of preterm labor under these conditions.
Keyword Interleukin-6
Prostaglandin Biosynthesis
Amnion
Decidua
Labor
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Other
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 23:02:58 EST