Prostaglandins during pregnancy and the perinatal period

Mitchell, Murray D. (1981) Prostaglandins during pregnancy and the perinatal period. Journal of Reproduction and Fertility, 62 1: 305-315. doi:10.1530/jrf.0.0620305

Author Mitchell, Murray D.
Title Prostaglandins during pregnancy and the perinatal period
Journal name Journal of Reproduction and Fertility   Check publisher's open access policy
ISSN 0022-4251
Publication date 1981-05-01
Sub-type Article (original research)
DOI 10.1530/jrf.0.0620305
Volume 62
Issue 1
Start page 305
End page 315
Total pages 11
Place of publication Oxford, England
Publisher Blackwell Scientific Publications
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Administration of prostaglandins (PGs) E-2 and F-2{alpha} will provoke contractions of the human uterus at any stage of pregnancy. The use of these compounds for the induction both of labour at term and of abortion is now widespread and well documented (Bygdeman, 1980). Recently, it has been found that PGs can effect cervical ripening and this property is being put to good clinical advantage (Bygdeman, 1980). There is evidence also that prostaglandin synthetase inhibitors (PGSI) can inhibit uterine contractions in pregnant and non-pregnant women (Wiqvist, 1979). Unfortunately, the therapeutic potential of PGSI, as a treatment for pre-term labour, is drastically reduced by the adverse side effect (now well documented) of closure of the ductus arteriosus in utero, after transplacental passage of the drug, leading to primary pulmonary hypertension of the newborn. The occurrence of this phenomenon is consistent with results from studies using experimental animals, strongly suggesting that PGE maintains the patency of the ductus arteriosus in utero (Coceani, Olley & Bodach, 1976).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 23:00:55 EST