Comparison of intrauterine prostaglandin metabolism during pregnancy in man, sheep and guinea pig

Keirse, M.J.N.C., Hicks, B.R., Kendall, J.Z. and Mitchell, M.D. (1978) Comparison of intrauterine prostaglandin metabolism during pregnancy in man, sheep and guinea pig. European Journal of Obstetrics Gynecology and Reproductive Biology, 8 4: 195-203. doi:10.1016/0028-2243(78)90015-1


Author Keirse, M.J.N.C.
Hicks, B.R.
Kendall, J.Z.
Mitchell, M.D.
Title Comparison of intrauterine prostaglandin metabolism during pregnancy in man, sheep and guinea pig
Journal name European Journal of Obstetrics Gynecology and Reproductive Biology   Check publisher's open access policy
ISSN 0301-2115
1872-7654
Publication date 1978-01-01
Sub-type Article (original research)
DOI 10.1016/0028-2243(78)90015-1
Volume 8
Issue 4
Start page 195
End page 203
Total pages 9
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Metabolism of prostaglandin F(2α) (PGF(2α)) was studied in uterine tissues from pregnant women (n = 10), sheep (n = 6) and guinea pigs (n = 6). Two maternal tissues, myometrium and decidua or maternal placenta, and 2 fetal tissues, fetal placenta and membranes, were studied in each species. PGF(2α) was metabolized via the well-known pathway into 15-keto-PGF(2α) and 13,14-dihydro-15-keto-PGF(2α), while 13,14-dihydro-PGF(2α) was tentatively identified in some tissues. The presence of 15-hydroxyprostaglandin dehydrogenase (PGDH) and 13,14-prostaglandin reductase was demonstrated in all tissues from each of the 3 species studied, but the quantitative intrauterine distribution of these enzymes differed from one species to another. In man, PGDH activities were highest in fetal membranes followed by fetal placenta and then by decidua and myometrium. In sheep, PGDH activities were highest in the maternal placenta followed in decreasing order by myometrium, fetal placenta and membranes. In the guinea pig, PGDH activity was highest in the fetal membranes followed in decreasing order by maternal placenta, fetal placenta and myometrium. Quantitative assay of PGDH showed that PGDH activity in the pregnant uterus is higher in women than in sheep and guinea pig. The results are discussed in relation to the involvement of prostaglandins in parturition.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 22:57:25 EST