Placental cytokines and preeclampsia

Keelan, Jeffery A. and Mitchell, Murray D. (2007) Placental cytokines and preeclampsia. Frontiers In Bioscience, 12 7: 2706-2727. doi:10.2741/2266

Author Keelan, Jeffery A.
Mitchell, Murray D.
Title Placental cytokines and preeclampsia
Journal name Frontiers In Bioscience   Check publisher's open access policy
ISSN 1093-4715
Publication date 2007-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2741/2266
Open Access Status Not Open Access
Volume 12
Issue 7
Start page 2706
End page 2727
Total pages 22
Place of publication Albertson, NY, United States
Publisher Frontiers in Bioscience
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Preeclampsia is a serious and life-threatening pregnancy complication. Reduced uteroplacental perfusion and oxygen tension, impaired trophoblast differentiation and invasion, and altered placental production of immunomodulators and growth factors are all considered to be important aspects in the aetiology of the condition. The placenta expresses a variety of pro and anti-inflammatory cytokines, adipokines and cytokine-like angiogenic growth factors, production of which is altered in preeclampsia, driven (at least in part) by hypoxia. Altered levels of cytokines have been measured in the circulation of women with preeclampsia, although for reasons that are not always apparent much of the data are disturbingly inconsistent. While the placenta undoubtedly makes an important contribution to plasma cytokine levels, production by maternal peripheral blood mononuclear cells (PBMCs) and other tissues is also likely to be significant, although to what extent remains undetermined. Increased placental expression of soluble receptors occurs with preeclampsia, resulting in elevated circulating concentrations which confer impaired angiogenesis, deficient placental vascularisation, increased placental apoptosis and endothelial dysfunction. The extent to which these changes reflect a response to the disorder, as opposed to being a causative factor in the development of maternal disease, is a matter of some debate. Nevertheless, convincing evidence is now accruing that autocrine/paracrine interactions between placental cytokines/growth factors and the maternal endothelium play a central role in the pathogenesis of preeclampsia.
Keyword Cytokines
Angiogenic growth factors
Endothelial Growth-factor
Blood Mononuclear-cells
Interleukin-1 Receptor Antagonist
Colony-stimulating Factor
Factor-Beta Superfamily
Serum Activin-A
Human Extravillous Trophoblast
Inducible Factor-i
Human Cytotrophoblast Differentiation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 40 times in Scopus Article | Citations
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Created: Thu, 26 Aug 2010, 22:56:23 EST