Neural mechanisms underlying spatial realignment during adaptation to optical wedge prisms

Chapman, Heidi L., Eramudugolla, Ranmalee, Gavrilescu, Maria, Strudwick, Mark W., Loftus, Andrea, Cunnington, Ross and Mattingley, Jason B. (2010) Neural mechanisms underlying spatial realignment during adaptation to optical wedge prisms. Neuropsychologia, 48 9: 2595-2601. doi:10.1016/j.neuropsychologia.2010.05.006


Author Chapman, Heidi L.
Eramudugolla, Ranmalee
Gavrilescu, Maria
Strudwick, Mark W.
Loftus, Andrea
Cunnington, Ross
Mattingley, Jason B.
Title Neural mechanisms underlying spatial realignment during adaptation to optical wedge prisms
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 0028-3932
1873-3514
Publication date 2010-07-01
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2010.05.006
Volume 48
Issue 9
Start page 2595
End page 2601
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Abstract Visuomotor adaptation to a shift in visual input produced by prismatic lenses is an example of dynamic sensory-motor plasticity within the brain. Prism adaptation is readily induced in healthy individuals, and is thought to reflect the brain’s ability to compensate for drifts in spatial calibration between different sensory systems. The neural correlate of this form of functional plasticity is largely unknown, although current models predict the involvement of parieto-cerebellar circuits. Recent studies that have employed event-related functional magnetic resonance imaging (fMRI) to identify brain regions associated with prism adaptation have discovered patterns of parietal and cerebellar modulation as participants corrected their visuomotor errors during the early part of adaptation. However, the role of these regions in the later stage of adaptation, when ‘spatial realignment’ or true adaptation is predicted to occur, remains unclear. Here, we used fMRI to quantify the distinctive patterns of parieto-cerebellar activity as visuomotor adaptation develops. We directly contrasted activation patterns during the initial error correction phase of visuomotor adaptation with that during the later spatial realignment phase, and found significant recruitment of the parieto-cerebellar network – with activations in the right inferior parietal lobe and the right posterior cerebellum. These findings provide the first evidence of both cerebellar and parietal involvement during the spatial realignment phase of prism adaptation. © 2010 Elsevier Ltd. All rights reserved.
Keyword Prism adaptation
Spatial cognition
Parietal lobe
Cerebellum
Spatial realignment
Error correction
fMRI
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 22 Aug 2010, 10:05:04 EST