Viruses in the faecal microbiota of monozygotic twins and their mothers

Reyes, Alejandro, Haynes, Matthew, Hanson, Nicole, Angly, Florent E., Heath, Andrew C., Rohwer, Forest and Gordon, Jeffrey I. (2010) Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature, 466 7304: 334-338. doi:10.1038/nature09199

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Author Reyes, Alejandro
Haynes, Matthew
Hanson, Nicole
Angly, Florent E.
Heath, Andrew C.
Rohwer, Forest
Gordon, Jeffrey I.
Title Viruses in the faecal microbiota of monozygotic twins and their mothers
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2010-07-15
Sub-type Article (original research)
DOI 10.1038/nature09199
Volume 466
Issue 7304
Start page 334
End page 338
Total pages 5
Editor Philip Campbell
Place of publication London, U.K
Publisher Nature Publishing Group
Language eng
Formatted abstract
Viral diversity and life cycles are poorly understood in the human gut and other body habitats. Phages and their encoded functions may provide informative signatures of a human microbiota and of microbial community responses to various disturbances, and may indicate whether community health or dysfunction is manifest after apparent recovery from a disease or therapeutic intervention. Here we report sequencing of the viromes (metagenomes) of virus-like particles isolated from faecal samples collected from healthy adult female monozygotic twins and their mothers at three time points over a one-year period. We compared these data sets with data sets of sequenced bacterial 16S ribosomal RNA genes and total-faecal-community DNA. Co-twins and their mothers share a significantly greater degree of similarity in their faecal bacterial communities than do unrelated individuals. In contrast, viromes are unique to individuals regardless of their degree of genetic relatedness. Despite remarkable interpersonal variations in viromes and their encoded functions, intrapersonal diversity is very low, with >95% of virotypes retained over the period surveyed, and with viromes dominated by a few temperate phages that exhibit remarkable genetic stability. These results indicate that a predatory viral-microbial dynamic, manifest in a number of other characterized environmental ecosystems, is notably absent in the very distal intestine.
© 2010 Macmillan Publishers Limited. All rights reserved.
Keyword Escherichia-coli
Viral communities
Genomic analysis
Phage predation
Human feces
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Advanced Water Management Centre Publications
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Citation counts: TR Web of Science Citation Count  Cited 380 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 402 times in Scopus Article | Citations
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Created: Sun, 25 Jul 2010, 10:03:51 EST