Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures

Moldrich, Randal X., Cheung, Nam S., Pascoe, Catherine J. and Beart, Philip M. (1999) Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures. European Journal of Pharmacology, 378 2: R1-R3. doi:10.1016/S0014-2999(99)00456-2


Author Moldrich, Randal X.
Cheung, Nam S.
Pascoe, Catherine J.
Beart, Philip M.
Title Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
1879-0712
Publication date 1999-08-01
Year available 1999
Sub-type Article (original research)
DOI 10.1016/S0014-2999(99)00456-2
Open Access Status Not Open Access
Volume 378
Issue 2
Start page R1
End page R3
Total pages 3
Publisher Elsevier Science B.V.
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
1109 Neurosciences
Abstract Neurotoxic profiles of putative agonists for low-affinity kainate subtypes of Image -glutamate receptors (GluR5-7) were determined in cultured cortical neurones. Rank order of neurotoxic potency (μM): (S)-5-iodowillardiine (9)≈(2S,4R,6E)-2-amino-4-carboxy-7-(2-naphthyl)hept-6-enoic acid (LY339434, 11)>(2S,4R)-4-methylglutamate (33)>kainate (100)>(RS)-2-amino-3-(hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid (ATPA, 360). Using ionotropic glutamate receptor antagonists, neurotoxicity induced by kainate, ATPA and (S)-5-iodowillardiine appeared to involve a GluR5-7 component, unlike LY339434 and (2S,4R)-4-methylglutamate. These putative GluR5-7 agonists exhibited complex excitotoxic profiles highlighting the importance of studying native glutamate receptors.
Keyword Kainate receptor
low-affinity
Cortical neurone
cultured
Excitotoxicity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Wed, 21 Jul 2010, 20:57:11 EST by Laura McTaggart on behalf of Queensland Brain Institute