Asthma and insulin resistance in children

Arshi, Mandana, Cardinal, John, Hill, Rebecca J., Davies, Peter S. W. and Wainwright, Claire (2010) Asthma and insulin resistance in children. Respirology, 15 5: 779-784. doi:10.1111/j.1440-1843.2010.01767.x

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Author Arshi, Mandana
Cardinal, John
Hill, Rebecca J.
Davies, Peter S. W.
Wainwright, Claire
Title Asthma and insulin resistance in children
Journal name Respirology   Check publisher's open access policy
ISSN 1323-7799
Publication date 2010-07-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1843.2010.01767.x
Volume 15
Issue 5
Start page 779
End page 784
Total pages 6
Place of publication Carlton, VIC, Australia
Publisher Blackwell Science
Language eng
Subject 1103 Clinical Sciences
1111 Nutrition and Dietetics
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Background and objective: Increased BMI is a risk factor for asthma in children and may be related to adipokines. Adipokines affect insulin-stimulated glucose uptake in vitro but, to date there is little evidence for such a role in vivo. We explored relationships between obesity and allergic asthma in children.
Methods: Twenty-one allergic asthmatics (AA) and 10 non-allergic healthy controls, aged 6-17.9 years were studied. AA group included children with a positive mannitol challenge test, >25 ppb of exhaled nitric oxide and a positive skin prick test. BMI z-scores were calculated. Blood levels of insulin, glucose, leptin, resistin, tumour necrosis factor-, IL-4, IL-5 and IL-6 were measured. Insulin resistance (IR) was estimated using the homeostasis model assessment (HOMA).
There was no significant difference in BMI z-scores between AA and healthy controls (mean: 0.01 vs-0.10). However, significant differences were found in the blood levels of IL-6 (P = 0.05), IL-4 (P = 0.04), IL-5 (P = 0.01) and leptin (P = 0.02). IR was only found in the AA group (42.85%). Homeostasis model assessment insulin resistance (HOMA-IR) was significantly related to IL-6 (r = 0.44, P = 0.05) and tumour necrosis factor-(r =-0.45, P = 0.05).
Conclusions: IR was observed in AA. Our findings are suggestive of a complex interaction between the inflammatory state and adiposity, allergy and asthma. © 2010 The Authors.
Keyword Adipokine
Body Mass Index
Insulin Resistance
Low-grade Inflammation
Incident Asthma
Obese Children
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 11 Jul 2010, 10:01:27 EST