Anxiety Disorders in Parkinson's Disease: Prevalence and Risk Factors

Dissanayaka, Nadeeka N. W., Sellbach, Anna, Matheson, Sally, O'Sullivan, John D., Silburn, Peter A., Byrne, Gerard J., Marsh, Rodney and Mellick, George D. (2010) Anxiety Disorders in Parkinson's Disease: Prevalence and Risk Factors. Movement Disorders, 25 7: 838-845. doi:10.1002/mds.22833

Author Dissanayaka, Nadeeka N. W.
Sellbach, Anna
Matheson, Sally
O'Sullivan, John D.
Silburn, Peter A.
Byrne, Gerard J.
Marsh, Rodney
Mellick, George D.
Title Anxiety Disorders in Parkinson's Disease: Prevalence and Risk Factors
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
Publication date 2010-05-15
Sub-type Article (original research)
DOI 10.1002/mds.22833
Open Access Status Not Open Access
Volume 25
Issue 7
Start page 838
End page 845
Total pages 8
Place of publication Hoboken, NJ
Publisher Wiley-Liss
Language eng
Formatted abstract
Anxiety disorders are common in Parkinson's disease (PD) patients, yet are poorly studied. We examined the prevalence of anxiety disorders in PD, investigated the association between anxiety, and presentation and progression of PD, and studied for the first time the contribution of putative risk factors for anxiety in PD. A case-series of 79 PD patients recruited from neurology out-patient clinics was examined for anxiety disorders using the DSM-IV criteria. The Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Staging of PD were employed to understand the relationship between anxiety disorders, and the clinical presentation and severity of PD. A validated survey assessed putative risk factors for anxiety in PD. Twenty-five percent of PD patients were diagnosed with anxiety. Panic disorder, generalised anxiety disorder and social phobia were prevalent anxiety disorders. Comorbid depression with anxiety was observed (14%). The severity but not the duration of PD was positively related to anxiety. PD patients with postural instability and gait dysfunction symptom clustering were more likely to experience anxiety than tremor-dominant patients. While levodopa dosage had no relationship to anxiety, experience of dyskinesias or on/off fluctuations increased the risk. Lateralisation of PD had no association with anxiety. Anxiety disorders decreased with age and young onset PD patients were more likely to experience anxiety than the late onset subjects. Anxiety adds to the complexity of PD, lowering patients' quality of life. Future research can be directed to identify reactive and organic nature of anxiety in PD. © 2010 Movement Disorder Society.
Keyword Prevalence
Risk factors
Parkinson's disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 110 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 126 times in Scopus Article | Citations
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Created: Sun, 20 Jun 2010, 10:03:19 EST