ER stress and the unfolded protein response in intestinal inflammation

McGuckin, Michael A., Eri, Rajaraman D., Das, Indrajit, Lourie, Rohan and Florin, Timothy H. (2010) ER stress and the unfolded protein response in intestinal inflammation. American Journal of Physiology: Gastrointestinal and Liver Physiology, 298 6: G820-G832. doi:10.1152/ajpgi.00063.2010


Author McGuckin, Michael A.
Eri, Rajaraman D.
Das, Indrajit
Lourie, Rohan
Florin, Timothy H.
Title ER stress and the unfolded protein response in intestinal inflammation
Journal name American Journal of Physiology: Gastrointestinal and Liver Physiology   Check publisher's open access policy
ISSN 0193-1857
1522-1547
Publication date 2010-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1152/ajpgi.00063.2010
Volume 298
Issue 6
Start page G820
End page G832
Total pages 23
Place of publication Bethesda, MD, U.S.A.
Publisher American Physiological Society
Collection year 2011
Language eng
Formatted abstract
Endoplasmic reticulum (ER) stress is a phenomenon that occurs when excessive protein misfolding occurs during biosynthesis. ER stress triggers a series of signaling and transcriptional events known as the unfolded protein response (UPR). The UPR attempts to restore homeostasis in the ER but if unsuccessful can trigger apoptosis in the stressed cells and local inflammation. Intestinal secretory cells are susceptible to ER stress because they produce large amounts of complex proteins for secretion, most of which are involved in mucosal defense. This review focuses on ER stress in intestinal secretory cells and describes how increased protein misfolding could occur in these cells, the process of degradation of misfolded proteins, the major molecular elements of the UPR pathway, and links between the UPR and inflammation. Evidence is reviewed from mouse models and human inflammatory bowel diseases that ties ER stress and activation of the UPR with intestinal inflammation, and possible therapeutic approaches to ameliorate ER stress are discussed.
Copyright © 2010 the American Physiological Society.
Keyword Endoplasmic reticulum
Protein misfolding
Goblet cell
Paneth cell
Inflammatory bowel diseases
Endoplasmic-reticulum stress
Factor-kappa-b
Alpha-defensin expression
Ubiquitin ligase complex
Genome-wide association
Airway epithelial-cells
Ileal crohns-disease
MUC gene-expression
Ulcerative-colitis
Bowel-disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 06 Jun 2010, 10:08:55 EST