Comparative mouse brain tractography of diffusion magnetic resonance imaging

Moldrich, Randal X., Pannek, Kerstin, Hoch, Renee, Rubenstein, John L., Kurniawan, Nyoman D. and Richards, Linda J. (2010) Comparative mouse brain tractography of diffusion magnetic resonance imaging. NeuroImage, 51 3: 1027-1036. doi:10.1016/j.neuroimage.2010.03.035

Author Moldrich, Randal X.
Pannek, Kerstin
Hoch, Renee
Rubenstein, John L.
Kurniawan, Nyoman D.
Richards, Linda J.
Title Comparative mouse brain tractography of diffusion magnetic resonance imaging
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2010-07-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2010.03.035
Open Access Status Not yet assessed
Volume 51
Issue 3
Start page 1027
End page 1036
Total pages 10
Place of publication Maryland Heights, MO, U.S.A.
Publisher Academic Press
Language eng
Subject 2808 Neurology
2805 Cognitive Neuroscience
Abstract Diffusion magnetic resonance imaging (dMRI) tractography can be employed to simultaneously analyze three-dimensional white matter tracts in the brain. Numerous methods have been proposed to model diffusion-weighted magnetic resonance data for tractography, and we have explored the functionality of some of these for studying white and grey matter pathways in ex vivo mouse brain. Using various deterministic and probabilistic algorithms across a range of regions of interest we found that probabilistic tractography provides a more robust means of visualizing both white and grey matter pathways than deterministic tractography. Importantly, we demonstrate the sensitivity of probabilistic tractography profiles to streamline number, step size, curvature, fiber orientation distribution threshold, and wholebrain versus region of interest seeding. Using anatomically well-defined corticothalamic pathways, we show how projection maps can permit the topographical assessment of probabilistic tractography. Finally, we show how different tractography approaches can impact on dMRI assessment of tract changes in a mouse deficient for the frontal cortex morphogen, fibroblast growth factor 17. In conclusion, probabilistic tractography can elucidate the phenotypes of mice with neurodegenerative or neurodevelopmental disorders in a quantitative manner. © 2010 Elsevier Inc.
Keyword Mouse brain
Diffusion-weighted imaging
Constrained spherical deconvolution
Neuronal fiber pathways
Living human brain
Axonal projections
Deficient mice
Tensor MRI
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 631552
RO1 N534661
1 F32 MH081431-01A2
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 41 times in Scopus Article | Citations
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Created: Sun, 30 May 2010, 10:01:28 EST