Dopaminergic modulation of arousal in Drosophila

Andretic, Rozi, van Swinderen, Bruno and Greenspan, Ralph J. (2005) Dopaminergic modulation of arousal in Drosophila. Current Biology, 15 13: 1165-1175. doi:10.1016/j.cub.2005.05.025

Author Andretic, Rozi
van Swinderen, Bruno
Greenspan, Ralph J.
Title Dopaminergic modulation of arousal in Drosophila
Journal name Current Biology   Check publisher's open access policy
ISSN 0960-9822
Publication date 2005-06-12
Sub-type Article (original research)
DOI 10.1016/j.cub.2005.05.025
Open Access Status Not yet assessed
Volume 15
Issue 13
Start page 1165
End page 1175
Total pages 11
Place of publication Cambridge, Mass. U.S.A.
Publisher Cell Press
Language eng
Subject 1109 Neurosciences
Formatted abstract
Arousal levels in the brain set thresholds for behavior, from simple to complex. The mechanistic underpinnings of the various phenomena comprising arousal, however, are still poorly understood. Drosophila behaviors have been studied that span different levels of arousal, from sleep to visual perception to psychostimulant responses.

We have investigated neurobiological mechanisms of arousal in the Drosophila brain by a combined behavioral, genetic, pharmacological, and electrophysiological approach. Administration of methamphetamine (METH) suppresses sleep and promotes active wakefulness, whereas an inhibitor of dopamine synthesis promotes sleep. METH affects courtship behavior by increasing sexual arousal while decreasing successful sexual performance. Electrophysiological recordings from the medial protocerebrum of wild-type flies showed that METH ingestion has rapid and detrimental effects on a brain response associated with perception of visual stimuli. Recordings in genetically manipulated animals show that dopaminergic transmission is required for these responses and that visual-processing deficits caused by attenuated dopaminergic transmission can be rescued by METH.

We show that changes in dopamine levels differentially affect arousal for behaviors of varying complexity. Complex behaviors, such as visual perception, degenerate when dopamine levels are either too high or too low, in accordance with the inverted-U hypothesis of dopamine action in the mammalian brain. Simpler behaviors, such as sleep and locomotion, show graded responses that follow changes in dopamine level. ©2005 Elsevier Ltd All rights reserved.
Keyword aromatic levo amino acid decarboxylase
Drosophila protein
shibire protein
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 190 times in Thomson Reuters Web of Science Article | Citations
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