Mango extracts and the mango component mangiferin promote endothelial cell migration

Daud, Noor Huda, Aung, Cho Sanda, Hewavitharana, Amitha K., Wilkinson, Ashley S., Pierson, Jean-Thomas, Roberts-Thomson, Sarah J., Shaw, P. Nicholas, Monteith, Gregory R., Gidley, Michael J. and Parat, Marie-Odile (2010) Mango extracts and the mango component mangiferin promote endothelial cell migration. Journal of Agricultural and Food Chemistry, 58 8: 5181-5186. doi:10.1021/jf100249s

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Author Daud, Noor Huda
Aung, Cho Sanda
Hewavitharana, Amitha K.
Wilkinson, Ashley S.
Pierson, Jean-Thomas
Roberts-Thomson, Sarah J.
Shaw, P. Nicholas
Monteith, Gregory R.
Gidley, Michael J.
Parat, Marie-Odile
Title Mango extracts and the mango component mangiferin promote endothelial cell migration
Journal name Journal of Agricultural and Food Chemistry   Check publisher's open access policy
ISSN 0021-8561
Publication date 2010-04-28
Sub-type Article (original research)
DOI 10.1021/jf100249s
Volume 58
Issue 8
Start page 5181
End page 5186
Total pages 6
Place of publication Easton, PA, U.S.A.
Publisher American Chemical Society
Language eng
Subject C1
060101 Analytical Biochemistry
060199 Biochemistry and Cell Biology not elsewhere classified
111102 Dietetics and Nutrigenomics
111601 Cell Physiology
820214 Tropical Fruit
920104 Diabetes
920102 Cancer and Related Disorders
Abstract This study tested the hypothesis that mango extracts contain bioactive molecules capable of modulating endothelial cell migration, an essential step in the formation of new blood vessels or angiogenesis. The formation of new blood vessels is an important therapeutic target for diseases such as limb ischemia, coronary infarction or stroke. We examined the effect of mango peel and flesh extracts as well as the individual polyphenolic molecules, mangiferin and quercetin, on bovine aortic cell migration using a modified Boyden chamber assay. Our results show that mangiferin, and extracts rich in mangiferin, increase endothelial cell migration. The dose−effect relationship for various extracts further suggests that this action of mangiferin is modulated by other components present in the extracts. The promigratory effect of mango extracts or mangiferin was unrelated to an effect on cell proliferation, and did not involve a change in the production of matrix metalloprotease-2 or -9 by the endothelial cells. Taken together, these results suggest that mangiferin present in mango extracts may have health promoting effects in diseases related to the impaired formation of new blood vessels. ©2010 American Chemical Society
Keyword Angiogenesis
Mango peel
Mango flesh
Boyden chamber
Liquid-chromatographic method
Folin-ciocalteu reagent
Angiogenesis in-vitro
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Pharmacy Publications
Centre for Nutrition and Food Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 30 times in Scopus Article | Citations
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Created: Sun, 02 May 2010, 10:05:46 EST