The effects of alcoholism on the human basolateral amygdala

Kryger, R. and Wilce, P. A. (2010) The effects of alcoholism on the human basolateral amygdala. Neuroscience, 167 2: 361-371. doi:10.1016/j.neuroscience.2010.01.061

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Author Kryger, R.
Wilce, P. A.
Title The effects of alcoholism on the human basolateral amygdala
Journal name Neuroscience   Check publisher's open access policy
ISSN 0306-4522
Publication date 2010-05-01
Sub-type Article (original research)
DOI 10.1016/j.neuroscience.2010.01.061
Open Access Status Not yet assessed
Volume 167
Issue 2
Start page 361
End page 371
Total pages 11
Place of publication Oxford
Publisher Pergamon
Language eng
Subject 2800 Neuroscience
Abstract Alcohol affects gene expression in several brain regions. The amygdala is a key structure in the brain’s emotional system and in recent years the crucial importance of the amygdala in drug-seeking and relapse has been increasingly recognized. In this study gene expression screening was used to identify genes involved in alcoholism in the human basolateral amygdala of male patients. The results show that alcoholism affects a broad range of genes and many systems including genes involved in synaptic transmission, neurotransmitter transport, structural plasticity, metabolism, energy production, transcription and RNA processing and the circadian cycle. In particular, genes involved in the glutamate system were affected in the alcoholic patients. In the amygdala the glutamate system is involved in the acquisition, consolidation, expression and extinction of associative learning, which is a vital part of addiction, and in alcohol abusers it is associated with withdrawal anxiety and neurodegeneration. Downregulation of the excitatory amino acid transporters GLAST, GLT-1 and the AMPA glutamate receptor 2 (GluR2) revealed by the microarray were confirmed by Western blots. The decreased expression of GLAST, GLT-1 and GluR2 in the alcoholic patients may increase glutamate tone and activity in the basolateral amygdala and this may contribute to neurodegeneration as well as the expression of associative memories and anxiety which underlie continued drug-seeking and chronic relapse. © 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Keyword Brain
Gene expression
Glutamate Transporter Glast
Prefrontal Cortex Responses
Cocaine-seeking behavior
Gated Calcium-channels
Long-term Potentiation
Adult-rat Hippocampus
Chronic Ethanol
Synaptic Plasticity
Conditioned fear
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Accepted 29 January 2010. Available online 11 February 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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Created: Sun, 02 May 2010, 10:02:33 EST