Reactions of cisplatin hydrolytes, cis-[Pt(15NH3)2(H2O) 2]2+, with N-acetyl-L-cysteine

Hadi, Sutopo and Appleton, Trevor G. (2010) Reactions of cisplatin hydrolytes, cis-[Pt(15NH3)2(H2O) 2]2+, with N-acetyl-L-cysteine. Russian Journal of Inorganic Chemistry, 55 2: 223-228. doi:10.1134/S0036023610020142

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Author Hadi, Sutopo
Appleton, Trevor G.
Title Reactions of cisplatin hydrolytes, cis-[Pt(15NH3)2(H2O) 2]2+, with N-acetyl-L-cysteine
Formatted title
Reactions of cisplatin hydrolytes, cis-[Pt(15NH3)2(H2O) 2]2+, with N-acetyl-L-cysteine
Journal name Russian Journal of Inorganic Chemistry   Check publisher's open access policy
ISSN 0036-0236
1531-8613
0044-457X
0044-457X
Publication date 2010-02-01
Sub-type Article (original research)
DOI 10.1134/S0036023610020142
Open Access Status DOI
Volume 55
Issue 2
Start page 223
End page 228
Total pages 6
Place of publication Moscow, Russian Federation
Publisher MAIK Nauka - Interperiodica
Language eng
Formatted abstract
The reaction of cis-[Pt(15NH3)2(H 2O)2]2+ (3) with N-acetylcysteine [H 3accys] was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. A monodentate sulfur-boundplatinum(II) product cis-[Pt(15NH3) 2(H2O)(H2accys-S)]+ (7) and six-membered chelate ring complex cis-[Pt(15NH3) 2(Haccys-S,O)] (8) were formed in solution. The dinuclear sulfur-bridged complex 9, giving a broad peak in 15N NMR, was also observed, but only present in very tiny amounts. The mass spectrometry (ES-MS) was undertaken from this reaction, and the product detected was only the dinuclear sulfur bridged platinum species and species related to it by ammine loss. © Pleiades Publishing, Ltd., 2010.
Keyword Chelate ring
Cross-linking
Amino-acids
Kinetics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Official 2011 Collection
 
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Created: Sun, 25 Apr 2010, 10:00:26 EST