On the determination of Darcy permeability coefficients for a microporous tissue scaffold

Wang, Yiwei, Tomlins, Paul E, Coombes, Allan G. A. and Rides, Martin (2010) On the determination of Darcy permeability coefficients for a microporous tissue scaffold. Tissue Engineering Part C- Methods, 16 2: 281-289. doi:10.1089/ten.tec.2009.0116

Author Wang, Yiwei
Tomlins, Paul E
Coombes, Allan G. A.
Rides, Martin
Title On the determination of Darcy permeability coefficients for a microporous tissue scaffold
Journal name Tissue Engineering Part C- Methods   Check publisher's open access policy
ISSN 1937-3384
Publication date 2010-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1089/ten.tec.2009.0116
Volume 16
Issue 2
Start page 281
End page 289
Total pages 9
Editor Antonios G. Mikos
Peter C. Johnson
Place of publication Rochelle, United States
Publisher Mary Ann Leibert, Inc. Publishers
Language eng
Subject C1
111504 Pharmaceutical Sciences
860899 Human Pharmaceutical Products not elsewhere classified
Formatted abstract
Structural characterization of porous tissue scaffolds is challenging due to their complexity. Most investigators report the porosity of the material together with an estimate of the mean pore size and the pore size distribution. The usefulness of these measures is limited, especially in predicting the time-dependent permeation characteristics of a biodegradable, cell-seeded scaffold. A potential solution to this problem is to measure the permeability of the matrix and determine the Darcy permeability coefficient. Darcy permeability coefficients of 3.1×10−14 and 6.3×10−14 m2 were measured for air and water, respectively, in microporous polycaprolactone scaffolds by monitoring fluid flow in response to a range of pressure differentials. Permeability coefficients for phosphate-buffered saline (5.3×10−14 m2), glucose (5.7×10−14 m2), and bovine serum albumin (1.8×10−14 m2) were obtained by monitoring the change in concentration of molecular probes. This approach revealed the efficiency of transport of glucose molecules through the porous material and the existence of protein–scaffold interactions that resulted in protein retention and a reduction in fluid permeation rate. Darcy permeability measurements can provide valuable insights concerning the transport properties of nutrients, metabolites, and polypeptide growth factors in porous tissue engineering scaffolds and a method of quality assurance in scaffold processing. © 2010, Mary Ann Liebert, Inc.
Keyword Drug delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Online Ahead of Print: November 18, 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
2010 Higher Education Research Data Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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Created: Sun, 18 Apr 2010, 10:00:39 EST