Prothrombinase complexes with different physiological roles

Lavin, Martin F. and Masci, Paul P. (2009) Prothrombinase complexes with different physiological roles. Thrombosis and Haemostasis, 102 3: 421-423. doi:10.1160/TH09-08-0050

Author Lavin, Martin F.
Masci, Paul P.
Title Prothrombinase complexes with different physiological roles
Journal name Thrombosis and Haemostasis   Check publisher's open access policy
ISSN 0340-6245
Publication date 2009-09-01
Sub-type Editorial
DOI 10.1160/TH09-08-0050
Volume 102
Issue 3
Start page 421
End page 423
Total pages 4
Editor Klaus T. Preissner
Place of publication Stuttgart, Germany
Publisher Schattauer
Language eng
Subject 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
060108 Protein Trafficking
Formatted abstract
The work reported by Kwong et al and Bos et al provide important mechanistic data that assist in explaining why such proteins with similar catalytic activity have evolved to perform quite different physiological functions. The focus here is the prothrombinase, the FXa-FVa complex, which functions in the blood to respond to injury and minimise bleeding. This functional role is highly conserved in a variety of species including snakes. In snakes a closely related prothrombinase complex has been recruited into the venom gland as a toxin to assist in immobilising prey by inducing a massive thrombotic event such as a disseminated intravascular coagulation. This evolution has been achieved by distinct processes for FXa- and FVa-like proteins.

The capacity of both venom factors to associate with members of the mammalian prothrombin activator provides the potential for the development of novel therapeutics capable of preventing blood loss both topically and when administered intraveneously.
© 2009 Schattauer GmbH, Stuttgart
Keyword Protein complex
Snake venom
Q-Index Code CX

Document type: Journal Article
Sub-type: Editorial
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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Created: Sat, 17 Apr 2010, 00:06:14 EST by Fiona Mactaggart on behalf of Medicine - Princess Alexandra Hospital