Epigenomic targets for the treatment of respiratory disease

Bowman, Rayleen V., Wright, Casey M., Davidson, Mprgan R., Francis, Santiyagu M., Yang, Ian A. and Fong, Kwun M. (2009) Epigenomic targets for the treatment of respiratory disease. Expert Opinion on Therapeutic Targets, 13 6: 625-640. doi:10.1517/14728220902926119

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Author Bowman, Rayleen V.
Wright, Casey M.
Davidson, Mprgan R.
Francis, Santiyagu M.
Yang, Ian A.
Fong, Kwun M.
Title Epigenomic targets for the treatment of respiratory disease
Journal name Expert Opinion on Therapeutic Targets   Check publisher's open access policy
ISSN 1472-8222
1744-7631
Publication date 2009-06-01
Year available 2009
Sub-type Article (original research)
DOI 10.1517/14728220902926119
Volume 13
Issue 6
Start page 625
End page 640
Total pages 16
Editor Fizah Khan
Place of publication London, UK
Publisher Informa Healthcare
Language eng
Subject C1
Formatted abstract
Background: A number of processes lead to epigenetic and epigenomic modifications. Objective: To address the importance of epigenomics in respiratory disease. Methods: Studies of epigenomics were analysed in relation to chronic respiratory diseases. Results/conclusion: In lung cancer and mesothelioma, a number of genes involved in carcinogenesis have been demonstrated to be hypermethylated, implicating epigenomic changes in the aetiology of these cancers. Hypermethylated genes have also been associated with lung cancer recurrence, indicating epigenomic regulation of metastasis. In airway diseases, modulation of histone function may activate inflammatory mechanisms in chronic obstructive pulmonary disease patients and lead to relative steroid resistance. There is emerging evidence for the role of epigenetic changes in chronic lung diseases such as asthma, including responses to environmental exposures in utero and to the effects of air pollution. Insight into epigenomics will lead to the development of novel biomarkers and treatment targets in respiratory diseases.
Keyword Asthma
Lung neoplasms
Epigenesis
DNA methylation
Chronic obstructive pulmonary disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 16 Apr 2010, 00:48:47 EST by Kasia Moore on behalf of Medicine - Prince Charles Hospital