Placental growth hormone, fetal growth and the IGF axis in normal and diabetic pregnancy

McIntyre, H.D., Russell, A. and Zeck, W. (2009) Placental growth hormone, fetal growth and the IGF axis in normal and diabetic pregnancy. Current Diabetes Reviews, 5 3: 185-189. doi:10.2174/157339909788920947


Author McIntyre, H.D.
Russell, A.
Zeck, W.
Title Placental growth hormone, fetal growth and the IGF axis in normal and diabetic pregnancy
Journal name Current Diabetes Reviews   Check publisher's open access policy
ISSN 1573-3998
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.2174/157339909788920947
Open Access Status Not Open Access
Volume 5
Issue 3
Start page 185
End page 189
Total pages 6
Editor Norman E. Cameron
Place of publication Netherlands
Publisher Bentham Science Publishers
Language eng
Subject C1
920507 Women's Health
111707 Family Care
Abstract Gestational diabetes mellitus (GDM) and pre-gestational diabetes are known to pose risks to the mother and developing fetus, often related to abnormal fetal growth. One potential mediator of maternal effects on fetal growth is Placental Growth Hormone (PGH). PGH is produced by the syncytiotrophoblast and found predominantly in the maternal circulation. It progressively replaces pituitary growth hormone (hGH) in the human maternal circulation from midgestation onwards, peaking towards term. PGH appears to be an important potential regulator of maternal insulin resistance in human pregnancy and may influence fetal growth both by modifying substrate availability and through paracrine actions in the placental bed. The details of PGH regulation remain relatively poorly understood, but current evidence does suggest a central role in growth restricted pregnancies. There is currently less evidence of a pathophysiologic role in production of the macrosomic fetal phenotype commonly seen in response to hyperglycaemia, although our recent in vitro studies do raise the possibility of feto-placental feedback as a mechanism of growth modulation.
Keyword Placental Growth Hormone
Diabetes
Pregnancy
Fetal Growth
Insulin-like Growth Factor-1;
Insulin Resistance
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Thu, 08 Apr 2010, 01:40:01 EST by Fiona Mactaggart on behalf of Medicine - Princess Alexandra Hospital