c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells

Isomura, I., Palmer, S., Grumont, R. J., Bunting, K., Hoyne, G., Wilkinson, N., Banerjee, A., Proietto, A., Gugasyan, R., Li, W., McNally, Alice, Steptoe, Raymond J., Thomas, Ranjeny, Shannon, F. and Gerondakis, S. (2009) c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells. The Journal of Experimental Medicine, 206 13: 3001-3014. doi:10.1084/jem.20091411

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Author Isomura, I.
Palmer, S.
Grumont, R. J.
Bunting, K.
Hoyne, G.
Wilkinson, N.
Banerjee, A.
Proietto, A.
Gugasyan, R.
Li, W.
McNally, Alice
Steptoe, Raymond J.
Thomas, Ranjeny
Shannon, F.
Gerondakis, S.
Title c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells
Journal name The Journal of Experimental Medicine   Check publisher's open access policy
ISSN 0022-1007
Publication date 2009-12-07
Year available 2009
Sub-type Article (original research)
DOI 10.1084/jem.20091411
Open Access Status File (Publisher version)
Volume 206
Issue 13
Start page 3001
End page 3014
Total pages 14
Editor j-L. Casanova
Place of publication United States
Publisher Rockefeller University Press
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
970106 Expanding Knowledge in the Biological Sciences
920108 Immune System and Allergy
060103 Cell Development, Proliferation and Death
1107 Immunology
Abstract During thymopoiesis, a unique program of gene expression promotes the development of CD4 regulatory T (T reg) cells. Although Foxp3 maintains a pattern of gene expression necessary for T reg cell function, other transcription factors are emerging as important determinants of T reg cell development. We show that the NF-kappa B transcription factor c-Rel is highly expressed in thymic T reg cells and that in c-rel(-/-) mice, thymic T reg cell numbers are markedly reduced as a result of a T cell-intrinsic defect that is manifest during thymocyte development. Although c-Rel is not essential for TGF-beta conversion of peripheral CD4(+)CD25(-) T cells into CD4(+)Foxp3(+) cells, it is required for optimal homeostatic expansion of peripheral T reg cells. Despite a lower number of peripheral T reg cells in c-rel(-/-) mice, the residual peripheral c-rel(-/-) T reg cells express normal levels of Foxp3, display a pattern of cell surface markers and gene expression similar to those of wild-type T reg cells, and effectively suppress effector T cell function in culture and in vivo. Collectively, our results indicate that c-Rel is important for both the thymic development and peripheral homeostatic proliferation of T reg cells.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 120 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 08 Apr 2010, 00:27:36 EST by Kylie Hengst on behalf of UQ Diamantina Institute