Microchimeric fetal cells cluster at sites of tissue injury in lung decades after pregnancy.

O'Donoghue, K., Sultan, H. A., Al-Allaf, F. A., Anderson, J. R., Wyatt-Ashmead, J. and Fisk, N. M. (2008) Microchimeric fetal cells cluster at sites of tissue injury in lung decades after pregnancy.. Reproductive BioMedicine Online, 16 3: 382-390.

Author O'Donoghue, K.
Sultan, H. A.
Al-Allaf, F. A.
Anderson, J. R.
Wyatt-Ashmead, J.
Fisk, N. M.
Title Microchimeric fetal cells cluster at sites of tissue injury in lung decades after pregnancy.
Journal name Reproductive BioMedicine Online   Check publisher's open access policy
ISSN 1472-6491
Publication date 2008-03-01
Year available 2008
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 16
Issue 3
Start page 382
End page 390
Total pages 9
Place of publication London, U.K.
Publisher Reproductive Healthcare
Language eng
Subject 1114 Paediatrics and Reproductive Medicine
Formatted abstract
Fetal cells trafficking into maternal blood during pregnancy engraft tissues and persist for decades in marrow and bone. While persistent fetal cells were initially implicated in autoimmune disease, animal studies suggest that microchimeric fetal cells play a broader role in response to tissue injury. This study investigated whether fetal cells participate in tissue repair after human pregnancy. Specimens were obtained from women undergoing surgery for suspected lung cancer. Y-fluorescence in-situ hybridization was performed on paraffin-embedded sections, with the investigator blinded to medical histories. Male cells were identified in lung/thymus tissue from all women with known male pregnancies, but not in those without sons. The frequency of male microchimeric cells was seven-fold greater in lung/thymus tissues than marrow and was two-fold greater than normal bone from the same women. Nested-polymerase chain reaction for sex determining region Y confirmed male DNA in tissues. Male cells in lung were clustered in tumour rather than surrounding healthy tissues. In conclusion, male presumed-fetal cells were identified in pathological post-reproductive tissues, where they were more likely to be located in diseased tissues at several-fold higher frequency than normal tissues. It is suggested that fetal cells are present at sites of tissue injury and may be stem cells, either recruited from marrow or having proliferated locally.
Keyword Adenocarcinoma/pathology
Squamous Cell/pathology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Health and Rehabilitation Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 06 Apr 2010, 21:38:17 EST by Ms May Balasaize on behalf of Faculty Of Health Sciences