Tissue transplantation by stealth — Coherent alginate microcapsules for immunoisolation

Leung, Andy, Nielsen, Lars K., Trau, Matt and Timmins, Nicholas E. (2010) Tissue transplantation by stealth — Coherent alginate microcapsules for immunoisolation. Biochemical Engineering Journal, 48 3: 337-347. doi:10.1016/j.bej.2009.10.007


Author Leung, Andy
Nielsen, Lars K.
Trau, Matt
Timmins, Nicholas E.
Title Tissue transplantation by stealth — Coherent alginate microcapsules for immunoisolation
Journal name Biochemical Engineering Journal   Check publisher's open access policy
ISSN 1369-703X
1873-295X
Publication date 2010-02-15
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.bej.2009.10.007
Volume 48
Issue 3
Start page 337
End page 347
Total pages 11
Editor Colin Webb
M .Taya
W. M. Miller
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Several of today's most prominent diseases arise as a result of aberrant secretory or enzymatic function, or loss of the corresponding tissue. While an obvious approach to treating these diseases is to simply replace the malfunctioning, damaged, or lost tissue, the need to immunosuppress recipients places them at increased risk of pathogenic infection and development of cancer. Limited availability of donor tissue is also problematic, and while xenogenic tissue could be used in some instances, immunosuppression alone is insufficient to prevent rejection. As an alternative, a physical barrier could be employed to mask the implanted tissue from immune surveillance at a local level, without the need for systemic immunosuppression. This approach is embodied through tissue microencapsulation. We review the underlying rationale of alginate based tissue microencapsulation technologies, current challenges, and possible solutions to these challenges in the form of a simple emulsion coating system incorporating functionalized alginate for local immunomodulation. ©2009 Elsevier BV. All rights reserved.
Keyword Encapsulation
Alginate
Transplant
Cell therapy
Emulsion
Membranes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received 9 July 2009; revised 7 October 2009; accepted 12 October 2009. Available online 20 October 2009.

 
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Created: Thu, 01 Apr 2010, 02:07:51 EST by Sharon Paterson on behalf of Aust Institute for Bioengineering & Nanotechnology