Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea

Trenholme, Katharine R., Boutlis, Craig S., Kuns, Rachel, Lagog, Moses, Bockarie, Moses J., Gatton, Michelle L., Kemp, David J., Good, Michael F., Anstey, Nicholas M. and Gardiner, Donald L. (2005) Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea. American Journal of Tropical Medicine and Hygiene, 72 6: 708-713.


Author Trenholme, Katharine R.
Boutlis, Craig S.
Kuns, Rachel
Lagog, Moses
Bockarie, Moses J.
Gatton, Michelle L.
Kemp, David J.
Good, Michael F.
Anstey, Nicholas M.
Gardiner, Donald L.
Title Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea
Journal name American Journal of Tropical Medicine and Hygiene   Check publisher's open access policy
ISSN 0002-9637
1476-1645
Publication date 2005-06-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 72
Issue 6
Start page 708
End page 713
Total pages 6
Place of publication Deerfield, IL, United States
Publisher American Society of Tropical Medicine and Hygiene
Language eng
Subject 1117 Public Health and Health Services
11 Medical and Health Sciences
Abstract The cytoadherence-linked asexual gene 9 (clag 9) of Plasmodium falciparum has been implicated in the cytoadherence of infected erythrocytes. To determine the immunogenicity of the clag 9 gene product (CLAG 9 protein) in humans, we measured antibody responses to 11 synthetic CLAG 9 peptides in a group of 177 asymptomatic children and adults subject to intense malaria exposure in Madang, Papua New Guinea. The CLAG 9 peptides were immunogenic in adults and children. Antibody responses to peptides 4 and 10 were high across all age groups and detectable in a majority of children less than five years of age. While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease.
Keyword Plasmodium falciparum
Malaria
CLAG 9 protein
Antibody responses
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Tue, 30 Mar 2010, 23:43:15 EST by Therese Egan on behalf of Faculty Of Health Sciences