The synthesis and biological evaluation of two analogues of the C-riboside showdomycin

Renner, J., Kruszelnicki, I., Adamiak, B., Willis, A.C., Hammond, E., Su, S., Burns, C., Trybala, E., Ferro, V. and Banwell, M.G. (2005) The synthesis and biological evaluation of two analogues of the C-riboside showdomycin. Australian Journal of Chemistry, 58 2: 86-93. doi:10.1071/CH04273


Author Renner, J.
Kruszelnicki, I.
Adamiak, B.
Willis, A.C.
Hammond, E.
Su, S.
Burns, C.
Trybala, E.
Ferro, V.
Banwell, M.G.
Title The synthesis and biological evaluation of two analogues of the C-riboside showdomycin
Journal name Australian Journal of Chemistry   Check publisher's open access policy
ISSN 0004-9425; 1448-0038
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1071/CH04273
Volume 58
Issue 2
Start page 86
End page 93
Total pages 8
Editor Curt Wentrup
Place of publication Melbourne, Australia
Publisher Commonwealth Scientific and Industrial Research Organization (CSIRO) in co-operation with the Australian Academy of Science
Language eng
Subject 0304 Medicinal and Biomolecular Chemistry
Formatted abstract
Two novel analogues, 2 and 3, of the C-riboside showdomycin (1) have been prepared by exploiting the N-TIPS-substituted pyrrole 7 as a synthetic equivalent for the maleimide C3 anion. The tetraacetate precursor, 12, of target 2 as well as target 3 itself were subjected to single-crystal X-ray analyses. Analogues 2 and 3 as well as showdomycin and its anomer (4) have each been evaluated in various assays for their cytotoxic, anti-bacterial, and anti-viral effects.
© CSIRO 2005.
Keyword Crystallography
Diffractometers
Diffusion
Nitrogen compounds
Anti-viral effects
C-nucleosides
C-riboside showdomycin
Flash chromatography
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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