Origin and evolution of the Notch signalling pathway: An overview from eukaryotic genomes

Gazave, Eve, Lapebie, Pascal, Richards, Gemma, Brunet, Frederic, Ereskovsky, Alexander, Degnan, Bernard M., Borchiellini, Carole, Vervoort, Michel and Renard, Emmanuelle (2009) Origin and evolution of the Notch signalling pathway: An overview from eukaryotic genomes. BMC Evolutionary Biology, 9 249: 249.1-249.27. doi:10.1186/1471-2148-9-249


Author Gazave, Eve
Lapebie, Pascal
Richards, Gemma
Brunet, Frederic
Ereskovsky, Alexander
Degnan, Bernard M.
Borchiellini, Carole
Vervoort, Michel
Renard, Emmanuelle
Title Origin and evolution of the Notch signalling pathway: An overview from eukaryotic genomes
Journal name BMC Evolutionary Biology   Check publisher's open access policy
ISSN 1471-2148
Publication date 2009-10-01
Sub-type Article (original research)
DOI 10.1186/1471-2148-9-249
Open Access Status DOI
Volume 9
Issue 249
Start page 249.1
End page 249.27
Total pages 27
Place of publication London, United Kingdom
Publisher Biomed Central
Language eng
Formatted abstract
Background: Of the 20 or so signal transduction pathways that orchestrate cell-cell interactions in metazoans, seven are involved during development. One of these is the Notch signalling pathway which regulates cellular identity, proliferation, differentiation and apoptosis via the developmental processes of lateral inhibition and boundary induction. In light of this essential role played in metazoan development, we surveyed a wide range of eukaryotic genomes to determine the origin and evolution of the components and auxiliary factors that compose and modulate this pathway.
Results: We searched for 22 components of the Notch pathway in 35 different species that represent 8 major clades of eukaryotes, performed phylogenetic analyses and compared the domain compositions of the two fundamental molecules: the receptor Notch and its ligands Delta/ Jagged. We confirm that a Notch pathway, with true receptors and ligands is specific to the Metazoa. This study also sheds light on the deep ancestry of a number of genes involved in this pathway, while other members are revealed to have a more recent origin. The origin of several components can be accounted for by the shuffling of pre-existing protein domains, or via lateral gene transfer. In addition, certain domains have appeared de novo more recently, and can be considered metazoan synapomorphies.
Conclusion
: The Notch signalling pathway emerged in Metazoa via a diversity of molecular mechanisms, incorporating both novel and ancient protein domains during eukaryote evolution. Thus, a functional Notch signalling pathway was probably present in Urmetazoa.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Biological Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 87 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 86 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 30 Mar 2010, 22:53:03 EST by Hayley Ware on behalf of School of Biological Sciences