The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation

Ferro, V., Hammond, E. and Fairweather, J. K. (2004) The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation. Mini Reviews in Medicinal Chemistry, 4 6: 693-702. doi:10.2174/1389557043403729


Author Ferro, V.
Hammond, E.
Fairweather, J. K.
Title The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation
Journal name Mini Reviews in Medicinal Chemistry   Check publisher's open access policy
ISSN 1389-5575
1875-5607
Publication date 2004-08-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/1389557043403729
Volume 4
Issue 6
Start page 693
End page 702
Total pages 10
Editor A. Paul Krapcho
Atta-ur Rahman
M. Iqbal Choudhary
Patrice Talaga
Place of publication Hilversum, The Netherlands; Boca Raton, FL, U.S.A.
Publisher Bentham Science Publishers
Language eng
Subject 0304 Medicinal and Biomolecular Chemistry
1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
Heparanase is an endo-β-glucuronidase that degrades the glycosaminoglycan heparan sulfate, a major component of the extracellular matrix and basement membranes, and has been implicated in such processes as inflammation, angiogenesis and metastasis. The identification of inhibitors of heparanase is an attractive approach towards developing new therapeutics for metastatic tumours and chronic inflammatory diseases. This review focuses on heparanase inhibitors that have been isolated or synthesised to date. More recent developments in the understanding of heparanase structure and function that may ultimately aid in the future design of inhibitors with improved potency and specificity, are also discussed.
© 2004 Bentham Science Publishers Ltd.
Keyword Heparanase
Glucuronidase
Heparan sulfate
Metastasis
Angiogenesis
Inflammation
Inhibitors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Created: Tue, 30 Mar 2010, 22:11:08 EST by June Temby on behalf of Faculty of Science