Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma

Zhao, ZZ, Duffy, DL, Thomas, SA, Martin, NG, Hayward, NK and Montgomery, GW (2009) Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma. Melanoma Research, 19 2: 80-85. doi:10.1097/CMR.0b013e328322fc45


Author Zhao, ZZ
Duffy, DL
Thomas, SA
Martin, NG
Hayward, NK
Montgomery, GW
Title Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma
Journal name Melanoma Research   Check publisher's open access policy
ISSN 0960-8931
Publication date 2009-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1097/CMR.0b013e328322fc45
Open Access Status Not yet assessed
Volume 19
Issue 2
Start page 80
End page 85
Total pages 6
Place of publication United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject C1
Abstract The prevalence of cutaneous malignant melanoma (CMM) has increased significantly in most Caucasian populations in recent decades. Both genetic and environmental risk factors are involved in the development of CMM. A germline mutation in the syntaxin 17 (STX17) gene of horses was recently identified, which causes premature hair graying and is associated with susceptibility to melanoma. We hypothesized that common germline variants in the STX17 gene might be associated with a predisposition to human CMM or might interact with other melanoma risk genes. We genotyped 26 tagging single nucleotide polymorphisms (SNPs) across the STX17 gene region in an Australian sample of 1560 melanoma cases and 1650 controls and performed logistic regression analysis to identify potential SNP interactions in a combined dataset. Our results do not support an association between CMM and any of the STX17 SNPs and provide no evidence for interactions between the melanoma risk SNP rs910873 on chromosome 20 and any of the STX17 SNPs. We conclude that common variants in the STX17 gene region do not play a key role in the pathogenesis of human melanoma.
Keyword melanoma
syntaxin 17
polymorphisms
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID CA88363
380385
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 25 Mar 2010, 04:58:24 EST by Amanda Jones on behalf of Medicine - Royal Brisbane and Women's Hospital