Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress

Connolly, David J., Soares Magalhaes, Ricardo J., Fuentes, Virgininia Luis, Boswood, Adrian, Cole, Georgina, Boag, Alisdair and Syme, Harriet M. (2009) Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress. Journal of Veterinary Cardiology, 11 Supp. 1: S41-S50. doi:10.1016/j.jvc.2009.03.001


Author Connolly, David J.
Soares Magalhaes, Ricardo J.
Fuentes, Virgininia Luis
Boswood, Adrian
Cole, Georgina
Boag, Alisdair
Syme, Harriet M.
Title Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress
Journal name Journal of Veterinary Cardiology   Check publisher's open access policy
ISSN 1760-2734
Publication date 2009-05-01
Sub-type Article (original research)
DOI 10.1016/j.jvc.2009.03.001
Open Access Status
Volume 11
Issue Supp. 1
Start page S41
End page S50
Total pages 10
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject C1
920499 Public Health (excl. Specific Population Health) not elsewhere classified
1117 Public Health and Health Services
Abstract Objectives: To determine if serum natriuretic peptide (NP) concentrations could distinguish cardiac from non-cardiac causes of respiratory distress (RD) in cats. Animals: Seventy-four cats from 1 university hospital were used. Methods: Serum NP concentrations were measured in 41 cats with non-cardiac respiratory distress (RD-NC) and compared to 33 cats with RD due to congestive heart failure (RD + CHF) using sandwich enzyme immunoassays (ELISA). Results: RD-NC cats had lower (P = 0.0001) median NT-proANP and NT-proBNP concentrations (614 and 45 fmol/mL, respectively) than RD + CHF cats (1690 and 523 fmol/mL, respectively). The area under the curve was 0.88 and 0.96 for the receiver operating curve analysis of the diagnostic accuracy of NT-proANP and NT-proBNP concentrations to discriminate RD + CHF from RD-NC cats (P = 0.036). An optimum cut-off concentration of 986 fmol/mL for NT-proANP and 220 fmol/mL for NT-proBNP accurately discriminated RD-NC from RC + CHF cats with a sensitivity of 93.8% and 93.9% and a specificity of 80.3% and 87.8%, respectively. Conclusions: Serum NP concentrations were different in RD + CHF cats compared to RD-NC cats. Evaluation of circulating NP concentrations may be helpful in the initial approach to cats presenting with respiratory distress, particularly if advances in ELISA technology result in a rapid cage-side test. © 2009 Elsevier B.V. All rights reserved.
Keyword Cardiac biomarkers
Respiratory distress
Sensitivity
Specificity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Public Health Publications
 
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Created: Wed, 24 Mar 2010, 00:35:22 EST by Geraldine Fitzgerald on behalf of Faculty Of Health Sciences