Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllum sundaicum with weak activity against the glucocorticoid receptor

Cao, Shugeng, Low, Kia-Ngee, Glover, Robert P., Crasta, Sharon C., Ng, Siewbee, Buss, Antony D. and Butler, Mark S. (2006) Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllum sundaicum with weak activity against the glucocorticoid receptor. Journal of Natural Products, 69 4: 707-709. doi:10.1021/np050528n


Author Cao, Shugeng
Low, Kia-Ngee
Glover, Robert P.
Crasta, Sharon C.
Ng, Siewbee
Buss, Antony D.
Butler, Mark S.
Title Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllum sundaicum with weak activity against the glucocorticoid receptor
Formatted title
Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllum sundaicum with weak activity against the glucocorticoid receptor
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
1520-6025
Publication date 2006-04-01
Year available 2006
Sub-type Article (original research)
DOI 10.1021/np050528n
Open Access Status Not yet assessed
Volume 69
Issue 4
Start page 707
End page 709
Total pages 3
Editor A. Kinghorn Douglas
Place of publication Cincinnati, OH, U.S.A.
Publisher American Chemical Society
Language eng
Subject 0601 Biochemistry and Cell Biology
0607 Plant Biology
Abstract Bioassay-directed fractionation using a glucocorticoid receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A (1) and B (2), from the leaves of Calophyllum sundaicum collected in Singapore. The structures of 1 and 2, which were established by spectroscopic methods, contain a 3-substituted hexanoic acid unit not previously reported in other polyprenylated acylphloroglucinols.
Formatted abstract
Bioassay-directed fractionation using a glucocorticoid receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A and B, from the leaves of Calophyllum sundaicum collected in Singapore. The structures of 1 and 2, which were established by spectroscopic methods, contain a 3-substituted hexanoic acid unit not previously reported in other polyprenylated acylphloroglucinols.
© 2006 American Chemical Society and American Society of Pharmacognosy.
Keyword Sundaicumones A and B
Bioassay-directed fractionation
Calophyllum sundaicum
3-substituted hexanoic acid
Polyprenylated acylphloroglucinols
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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