An atlas of combinatorial transcriptional regulation in mouse and man

Ravasi, Timothy, Suzuki, Harukazu, Cannistraci, Carlo Vittorio, Katayama, Shintaro, Bajic, Vladimir B., Tan, Kai, Akalin, Altuna, Schmeier, Sebastian, Kanamori-Katayama, Mutsumi, Carninci, Piero, Bertin, Nicholas, Daub, Cartsten O., Forrest, Alistair R. R., Gough, Julian, Grimmond, Sean, Han, Jung-Hoon, Hashimoto, Takehiro, Hide, Winston, Hofmann, Oliver, Kamburov, Atanas, Kaur, Mandeep, Kawaji, Hideya, Kubosaki, Atsutaka, Lassmann, Timo, van Nimwegen, Erik, MacPherson, Cameron Ross, Ogawa, Chihiro, Radovanovic, Aleksandar, Schwartz, Ariel, Teasdale, Rohan D., Tegner, Jesper, Lenhard, Boris, Teichmann, Sarah A., Arakawa, Takahiro, Ninomiya, Noriko, Murakami, Kayoko, Tagami, Michihira, Fukuda, Shiro, Imamura, Kengo, Kai, Chikatoshi, Ishihara, Ryoko, Kitazume, Yayoi, Kawai, Jun, Hume, David A., Ideker, Trey and Hayashizaki, Yoshihide (2010) An atlas of combinatorial transcriptional regulation in mouse and man. Cell, 140 5: 744-752. doi:10.1016/j.cell.2010.01.044

Author Ravasi, Timothy
Suzuki, Harukazu
Cannistraci, Carlo Vittorio
Katayama, Shintaro
Bajic, Vladimir B.
Tan, Kai
Akalin, Altuna
Schmeier, Sebastian
Kanamori-Katayama, Mutsumi
Carninci, Piero
Bertin, Nicholas
Daub, Cartsten O.
Forrest, Alistair R. R.
Gough, Julian
Grimmond, Sean
Han, Jung-Hoon
Hashimoto, Takehiro
Hide, Winston
Hofmann, Oliver
Kamburov, Atanas
Kaur, Mandeep
Kawaji, Hideya
Kubosaki, Atsutaka
Lassmann, Timo
van Nimwegen, Erik
MacPherson, Cameron Ross
Ogawa, Chihiro
Radovanovic, Aleksandar
Schwartz, Ariel
Teasdale, Rohan D.
Tegner, Jesper
Lenhard, Boris
Teichmann, Sarah A.
Arakawa, Takahiro
Ninomiya, Noriko
Murakami, Kayoko
Tagami, Michihira
Fukuda, Shiro
Imamura, Kengo
Kai, Chikatoshi
Ishihara, Ryoko
Kitazume, Yayoi
Kawai, Jun
Hume, David A.
Ideker, Trey
Hayashizaki, Yoshihide
Title An atlas of combinatorial transcriptional regulation in mouse and man
Journal name Cell   Check publisher's open access policy
ISSN 0092-8674
Publication date 2010-03-05
Sub-type Article (original research)
DOI 10.1016/j.cell.2010.01.044
Volume 140
Issue 5
Start page 744
End page 752
Total pages 9
Place of publication Cambridge, MA, United
Publisher Cell Press
Collection year 2011
Language eng
Subject C1
0601 Biochemistry and Cell Biology
Formatted abstract
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution.
©2010 Elsevier Inc.

Keyword Embryonic stem-cells
Protein interactions
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 336 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 358 times in Scopus Article | Citations
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Created: Sun, 21 Mar 2010, 10:09:15 EST