Effects of anesthetic agents on socially transmitted olfactory memories in mice

Burne, T. H. J., Johnston, A. N. B., Wilkinson, L. S. and Kendrick, K. M. (2010) Effects of anesthetic agents on socially transmitted olfactory memories in mice. Neurobiology of Learning and Memory, 93 2: 268-274. doi:10.1016/j.nlm.2009.10.007

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Author Burne, T. H. J.
Johnston, A. N. B.
Wilkinson, L. S.
Kendrick, K. M.
Title Effects of anesthetic agents on socially transmitted olfactory memories in mice
Journal name Neurobiology of Learning and Memory   Check publisher's open access policy
ISSN 1074-7427
Publication date 2010-02-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.nlm.2009.10.007
Volume 93
Issue 2
Start page 268
End page 274
Total pages 7
Editor P. E. Gold
Place of publication San Diego, CA, U.S.A.
Publisher Academic Press
Language eng
Formatted abstract
Mice can learn a food preference from odor cues transmitted on the breath of a conspecific, even if the "demonstrator" is anesthetized. To our knowledge there are no studies examining the effect of anesthetizing the "observer" on development of memory for socially transmitted food preferences (STFP). In Experiment 1 we found that 2-4 month-old F2 C57Bl/6x129sv male and female mice demonstrated a STFP after a 5 min exposure to an anesthetized demonstrator mouse when tested 24 h later. In Experiment 2, observer mice anesthetized with Sagatal (60 mg/kg) prior to the "social interaction" preferentially avoided the cued food when tested 24 h later. This aversion was not due to any overt aversive effects of this dose of Sagatal because mice that ate the food and were then anesthetized, or could only smell the food for 5 min while anesthetized, showed no preference or aversion. In a third experiment we found that the Sagatal-induced aversion was not a general property of anesthesia because there were varied results produced by observer mice treated with anesthetic drugs with different mechanisms of action. Vetalar (200 mg/kg) and Rompun (10 mg/kg) treated animals ate similar amounts of cued and non-cued food at test, indicating an absence of learning. Hypnorm (0.5 ml/kg) treated animals showed a preference for the cued food whereas those treated with Hypnovel (2.5 ml/kg) showed an aversion to the cued food. These results show that the food aversion observed with Sagatal is not a general property of anesthetic agents, but appears to be restricted to those acting primarily on the GABAergic system. Thus, we have shown that under certain conditions it is possible for an anesthetized observer mouse to learn a preference or aversion of a socially-linked olfactory cue.
Crown Copyright © 2009. Published by Elsevier Inc. All rights reserved.
Keyword Olfactory learning
Food neophobia
Non-spatial relational memory
Rats rattus-norvegicus
Food preference
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 21 Mar 2010, 10:02:04 EST