The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

Canna, K., McArdle, P. A., McMillan, D. C., McNicol, A-M., Smith, G. W., McKee, R. F. and McArdle, C. S. (2005) The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. British Journal of Cancer, 92 4: 651-654. doi:10.1038/sj.bjc.6602419


Author Canna, K.
McArdle, P. A.
McMillan, D. C.
McNicol, A-M.
Smith, G. W.
McKee, R. F.
McArdle, C. S.
Title The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2005-02-01
Sub-type Article (original research)
DOI 10.1038/sj.bjc.6602419
Open Access Status DOI
Volume 92
Issue 4
Start page 651
End page 654
Total pages 4
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours. The aim of the present study was to examine the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory response and cancer-specific survival in patients with colorectal cancer. In all, 147 patients undergoing potentially curative resection for colorectal cancer were studied. Circulating concentrations of C-reactive protein were measured prior to surgery. CD4+ and CD8+ T-lymphocyte infiltration of the tumour was assessed using immunohistochemistry and a point counting technique. When patients were grouped according to the percentage tumour volume of CD4+ T-lymphocytes, there was no difference in terms of age, sex, tumour site, stage and tumour characteristics. However, there was an inverse relationship between percentage tumour CD4+ T-lymphocytes and C-reactive protein (P<0.01). On univariate analysis, both C-reactive protein concentrations (P<0.001) and percentage tumour volume of CD4+ (P<0.05) T-lymphocytes were associated with cancer-specific survival. The results of the present study show that low tumour CD4+ T-lymphocyte infiltration is associated with elevated C-reactive protein concentrations and both predict poor cancer-specific survival.
Keyword colorectal cancer
CD4+ and CD8+ T-lymphocytes
C-reactive protein
survival
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 17 Mar 2010, 02:04:25 EST by Laura McTaggart on behalf of Faculty Of Health Sciences