Rotavirus vaccines: Opportunities and challenges

Grimwood, Keith and Lambert, Stephen B. (2009) Rotavirus vaccines: Opportunities and challenges. Human Vaccines, 5 2: 57-69. doi:10.4161/hv.5.2.6924

Author Grimwood, Keith
Lambert, Stephen B.
Title Rotavirus vaccines: Opportunities and challenges
Journal name Human Vaccines   Check publisher's open access policy
ISSN 1554-8600
Publication date 2009-02-01
Year available 2009
Sub-type Article (original research)
DOI 10.4161/hv.5.2.6924
Volume 5
Issue 2
Start page 57
End page 69
Total pages 13
Editor Ronald W. Ellis
Place of publication United States of America
Publisher Landes Bioscience
Language eng
Subject 060501 Bacteriology
060502 Infectious Agents
060506 Virology
920109 Infectious Diseases
920105 Digestive System Disorders
Abstract Each year rotavirus gastoenteritis episodes in young children cause more than 500,000 deaths and 2.4 million hospital adminissions worldwide. Vaccine development became a priority when improved personal hygiene and living standards failed to significantly reduce this disease burden. Rotavirus vaccines were developed mimicking natural immunity by protecting against severe gastroenteritis in young children, which would otherwise lead to health-care attendance, hospitalisation or even death. Licensed rotavirus vaccines appear safe and are well-tolerated. In high and middle-income countries they provide 80-100% protection against severe disease and 70-80% protection against rotavirus gastroenteritis of any severity, depending upon the population studied. However, rotavirus vaccines remain to be fully evaluated in low-income countries where reduced immunogenicity of oral vaccines, greater strain diversity and difficulties reaching target populations might decrease immunisation programme performance. Nevertheless, if these challenges are met, rotavirus vaccines should help reduce the 5% of all childhood deaths attributable to rotavirus gastroenteritis.
Keyword Rotavirus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Wed, 10 Mar 2010, 20:19:54 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre