Associations between mucosal innate and adaptive immune responses and resolution of diarrheal pathogen infections

Long, Kurt Z., Rosado, Jorge L., Santos, Jose Ignacio, Haas, Meredith, Al Mamun, Abdullah, DuPont, Herbert L., Nanthakumar, Nanda N. and Estrada-Garcia, Teresa (2010) Associations between mucosal innate and adaptive immune responses and resolution of diarrheal pathogen infections. Infection and Immunity, 78 3: 1221-1228. doi:10.1128/IAI.00767-09

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Author Long, Kurt Z.
Rosado, Jorge L.
Santos, Jose Ignacio
Haas, Meredith
Al Mamun, Abdullah
DuPont, Herbert L.
Nanthakumar, Nanda N.
Estrada-Garcia, Teresa
Title Associations between mucosal innate and adaptive immune responses and resolution of diarrheal pathogen infections
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 1098-5522
Publication date 2010-03-01
Year available 2009
Sub-type Article (original research)
DOI 10.1128/IAI.00767-09
Open Access Status File (Publisher version)
Volume 78
Issue 3
Start page 1221
End page 1228
Total pages 8
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
The identification of immune response mechanisms that contribute to the control of diarrheal disease in developing countries remains an important priority. We addressed the role of fecal chemokines and cytokines in the resolution of diarrheal Escherichia coli and Giardia lamblia infections. Stools collected from 127 Mexican children 5 to 15 months of age enrolled in a randomized, double-blind, placebo-controlled, vitamin A supplementation trial were screened for enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli (ETEC), and Giardia lamblia. Fecal concentrations of tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), interleukin-4 (IL-4), IL-5, IL-6, IL-8, IL-10, and interferon-γ (IFN-γ) were determined. Hazard models incorporating cytokine variables were fit to durations of asymptomatic and symptomatic pathogen infections, controlling for treatment group. Increased levels of TNF-α and IL-6 were associated with decreased durations of EPEC infection and increased ETEC durations. Increased IL-4 and IFN-γ levels were associated with decreased and increased durations, respectively, of both EPEC and ETEC infections. Increased IL-10 levels were associated with increased and decreased durations of asymptomatic and symptomatic EPEC infections, respectively, and increased durations of both asymptomatic and symptomatic ETEC infections. Increased levels of MCP-1, IFN-γ, IL-4, and IL-5 were associated with increased G. lamblia infection duration, while increased IL-8 levels were associated with decreased durations. Differences in proinflammatory and Treg cytokine levels are associated with differences in the resolution of inflammatory and noninflammatory pathogen infections.
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Keyword Enterotoxigenic Escherichia-coli
Intestinal epithelial-cells
Vitamin-A supplementaion
Citrobacter-rodentium infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published ahead of print on 28 December 2009.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Public Health Publications
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Created: Sun, 07 Mar 2010, 10:04:09 EST